Cargando…

Role of exercise on molecular mechanisms in the regulation of antidepressant effects

Regular exercise reduces depressive-like behavior activation. In this study, we look for exact roles of exercise on molecular and neuronal mechanisms for antidepressant action by studying the hippocampal neuroplasticity and proliferation. Increased hippocampal neurogenesis with exercise has potentia...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Hyo-Jun, Baek, Seung-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Exercise Rehabilitation 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747194/
https://www.ncbi.nlm.nih.gov/pubmed/29326891
http://dx.doi.org/10.12965/jer.1735188.594
_version_ 1783289241885736960
author Lee, Hyo-Jun
Baek, Seung-Soo
author_facet Lee, Hyo-Jun
Baek, Seung-Soo
author_sort Lee, Hyo-Jun
collection PubMed
description Regular exercise reduces depressive-like behavior activation. In this study, we look for exact roles of exercise on molecular and neuronal mechanisms for antidepressant action by studying the hippocampal neuroplasticity and proliferation. Increased hippocampal neurogenesis with exercise has potential significance for depression. Exercise promotes brain health in the molecular levels in the hippocampus and also affects behavior in a similar way to chronic antidepressant treatment. Wingless (Wnt) and frizzled signaling system plays an important role in cell proliferation, growth, and differentiation during development. Our results demonstrate complicated, differential effects of antidepressants on Wnt signaling system, and assume a role for selected signaling molecules in the neurogenic activity of antidepressant care. Our review suggests that exercise may preserve brain function by increasing neurogenesis through activating Wnt signaling pathway in the psychiatric disorders, such as depression.
format Online
Article
Text
id pubmed-5747194
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Korean Society of Exercise Rehabilitation
record_format MEDLINE/PubMed
spelling pubmed-57471942018-01-11 Role of exercise on molecular mechanisms in the regulation of antidepressant effects Lee, Hyo-Jun Baek, Seung-Soo J Exerc Rehabil Review Article Regular exercise reduces depressive-like behavior activation. In this study, we look for exact roles of exercise on molecular and neuronal mechanisms for antidepressant action by studying the hippocampal neuroplasticity and proliferation. Increased hippocampal neurogenesis with exercise has potential significance for depression. Exercise promotes brain health in the molecular levels in the hippocampus and also affects behavior in a similar way to chronic antidepressant treatment. Wingless (Wnt) and frizzled signaling system plays an important role in cell proliferation, growth, and differentiation during development. Our results demonstrate complicated, differential effects of antidepressants on Wnt signaling system, and assume a role for selected signaling molecules in the neurogenic activity of antidepressant care. Our review suggests that exercise may preserve brain function by increasing neurogenesis through activating Wnt signaling pathway in the psychiatric disorders, such as depression. Korean Society of Exercise Rehabilitation 2017-12-27 /pmc/articles/PMC5747194/ /pubmed/29326891 http://dx.doi.org/10.12965/jer.1735188.594 Text en Copyright © 2017 Korean Society of Exercise Rehabilitation This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lee, Hyo-Jun
Baek, Seung-Soo
Role of exercise on molecular mechanisms in the regulation of antidepressant effects
title Role of exercise on molecular mechanisms in the regulation of antidepressant effects
title_full Role of exercise on molecular mechanisms in the regulation of antidepressant effects
title_fullStr Role of exercise on molecular mechanisms in the regulation of antidepressant effects
title_full_unstemmed Role of exercise on molecular mechanisms in the regulation of antidepressant effects
title_short Role of exercise on molecular mechanisms in the regulation of antidepressant effects
title_sort role of exercise on molecular mechanisms in the regulation of antidepressant effects
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747194/
https://www.ncbi.nlm.nih.gov/pubmed/29326891
http://dx.doi.org/10.12965/jer.1735188.594
work_keys_str_mv AT leehyojun roleofexerciseonmolecularmechanismsintheregulationofantidepressanteffects
AT baekseungsoo roleofexerciseonmolecularmechanismsintheregulationofantidepressanteffects