The NAPRESSIM trial: the use of low-dose, prophylactic naloxone infusion to prevent respiratory depression with intrathecally administered morphine in elective hepatobiliary surgery: a study protocol and statistical analysis plan for a randomised controlled trial

BACKGROUND: Intrathecally administered morphine is effective as part of a postoperative analgesia regimen following major hepatopancreaticobiliary surgery. However, the potential for postoperative respiratory depression at the doses required for effective analgesia currently limits its clinical use....

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Detalles Bibliográficos
Autores principales: Cosgrave, David, Galligan, Marie, Soukhin, Era, McMullan, Victoria, McGuinness, Siobhan, Puttappa, Anand, Conlon, Niamh, Boylan, John, Hussain, Rabia, Doran, Peter, Nichol, Alistair
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747267/
https://www.ncbi.nlm.nih.gov/pubmed/29284510
http://dx.doi.org/10.1186/s13063-017-2370-0

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