Systems Pharmacology Dissection of Cholesterol Regulation Reveals Determinants of Large Pharmacodynamic Variability between Cell Lines

In individuals, heterogeneous drug-response phenotypes result from a complex interplay of dose, drug specificity, genetic background, and environmental factors, thus challenging our understanding of the underlying processes and optimal use of drugs in the clinical setting. Here, we use mass-spectrom...

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Detalles Bibliográficos
Autores principales: Blattmann, Peter, Henriques, David, Zimmermann, Michael, Frommelt, Fabian, Sauer, Uwe, Saez-Rodriguez, Julio, Aebersold, Ruedi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747350/
https://www.ncbi.nlm.nih.gov/pubmed/29226804
http://dx.doi.org/10.1016/j.cels.2017.11.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747350/
https://www.ncbi.nlm.nih.gov/pubmed/29226804
http://dx.doi.org/10.1016/j.cels.2017.11.002

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