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Salt-inducible kinase 3 regulates the mammalian circadian clock by destabilizing PER2 protein

Salt-inducible kinase 3 (SIK3) plays a crucial role in various aspects of metabolism. In the course of investigating metabolic defects in Sik3-deficient mice (Sik3(-/-)), we observed that circadian rhythmicity of the metabolisms was phase-delayed. Sik3(-/-) mice also exhibited other circadian abnorm...

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Detalles Bibliográficos
Autores principales:	Hayasaka, Naoto, Hirano, Arisa, Miyoshi, Yuka, Tokuda, Isao T, Yoshitane, Hikari, Matsuda, Junichiro, Fukada, Yoshitaka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2017
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747517/ https://www.ncbi.nlm.nih.gov/pubmed/29227248 http://dx.doi.org/10.7554/eLife.24779

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