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In vitro antitumor activity of patulin on cervical and colorectal cancer cell lines

BACKGROUND AND PURPOSE: Patulin is a mycotoxin produced by some molds, especially Aspergillus and Penicilium, and is responsible for mycotoxicosis in animals and humans. There is still not very detailed data about the anti-cancer potency of patulin, but some reports demonstrated that it induces cell...

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Detalles Bibliográficos
Autores principales: Abastabar, M, Akbari, A, Akhtari, J, Hedayati, MT, Shokohi, T, Mehrad-Majd, H, Ghalehnoei, H, Ghasemi, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mazandaran University of Medical Sciences 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747586/
https://www.ncbi.nlm.nih.gov/pubmed/29302627
http://dx.doi.org/10.29252/cmm.3.1.25
Descripción
Sumario:BACKGROUND AND PURPOSE: Patulin is a mycotoxin produced by some molds, especially Aspergillus and Penicilium, and is responsible for mycotoxicosis in animals and humans. There is still not very detailed data about the anti-cancer potency of patulin, but some reports demonstrated that it induces cellular apoptosis and toxicity. MATERIALS AND METHODS: To determine the efficacy of patulin as a therapeutic strategy for cervical and colorectal cancers, we investigated its effects on HeLa,SW-48, and MRC-5 cell lines. Cell lines were exposed to various concentrations of patulin (i.e., 0.5, 1, 2, and 4 µM), then using methyl thiazolyl tetrazolium (MTT) and bromo-2′-deoxyuridine (BrdU) assays, the rates of apoptosis and cell viability were determined. RESULTS: The obtained results showed a significant reduction in cell viability and apoptosis induction in a dose-dependent manner. Among all the cell lines, the highest growth inhibition rate was obtained at the 4 μM concentration of patulin. CONCLUSION: Our results suggested that patulin could significantly decrease tumor growth in human cervical and colorectal cancer models.