Computer-aided design of multi-target ligands at A(1)R, A(2A)R and PDE10A, key proteins in neurodegenerative diseases

Compounds designed to display polypharmacology may have utility in treating complex diseases, where activity at multiple targets is required to produce a clinical effect. In particular, suitable compounds may be useful in treating neurodegenerative diseases by promoting neuronal survival in a synerg...

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Detalles Bibliográficos
Autores principales: Kalash, Leen, Val, Cristina, Azuaje, Jhonny, Loza, María I., Svensson, Fredrik, Zoufir, Azedine, Mervin, Lewis, Ladds, Graham, Brea, José, Glen, Robert, Sotelo, Eddy, Bender, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748027/
https://www.ncbi.nlm.nih.gov/pubmed/29290010
http://dx.doi.org/10.1186/s13321-017-0249-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748027/
https://www.ncbi.nlm.nih.gov/pubmed/29290010
http://dx.doi.org/10.1186/s13321-017-0249-4

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