Cargando…

Computer-aided design of multi-target ligands at A(1)R, A(2A)R and PDE10A, key proteins in neurodegenerative diseases

Compounds designed to display polypharmacology may have utility in treating complex diseases, where activity at multiple targets is required to produce a clinical effect. In particular, suitable compounds may be useful in treating neurodegenerative diseases by promoting neuronal survival in a synerg...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kalash, Leen, Val, Cristina, Azuaje, Jhonny, Loza, María I., Svensson, Fredrik, Zoufir, Azedine, Mervin, Lewis, Ladds, Graham, Brea, José, Glen, Robert, Sotelo, Eddy, Bender, Andreas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748027/ https://www.ncbi.nlm.nih.gov/pubmed/29290010 http://dx.doi.org/10.1186/s13321-017-0249-4

Ejemplares similares

Structure‐based identification of dual ligands at the A(2A)R and PDE10A with anti‐proliferative effects in lung cancer cell‐lines
por: Kalash, Leen, et al.
Publicado: (2021)

Orthologue chemical space and its influence on target prediction
por: Mervin, Lewis H, et al.
Publicado: (2018)

Human Genome Replication Proceeds through Four Chromatin States
por: Julienne, Hanna, et al.
Publicado: (2013)

Synthesis and Characterization of a New Bivalent Ligand Combining Caffeine and Docosahexaenoic Acid
por: Fernández-Dueñas, Víctor, et al.
Publicado: (2017)

Optimization of 2-Amino-4,6-diarylpyrimidine-5-carbonitriles as Potent and Selective A(1) Antagonists
por: Val, Cristina, et al.
Publicado: (2022)

Exploring Non-orthosteric Interactions with a Series of Potent and Selective A(3) Antagonists
por: Miranda-Pastoriza, Darío, et al.
Publicado: (2022)

Development of Fluorescent Probes that Target Serotonin 5-HT(2B) Receptors
por: Azuaje, Jhonny, et al.
Publicado: (2017)

A(2B) adenosine receptor antagonists rescue lymphocyte activity in adenosine-producing patient-derived cancer models
por: Tay, Apple Hui Min, et al.
Publicado: (2022)

Targeting PDE10A GAF Domain with Small Molecules: A Way for Allosteric Modulation with Anti-Inflammatory Effects
por: García, Ana M., et al.
Publicado: (2017)

Exploring the Effect of Halogenation in a Series of Potent and Selective A(2B) Adenosine Receptor Antagonists
por: Prieto-Díaz, Rubén, et al.
Publicado: (2022)

Numerical PDE analysis of retinal neovascularization: mathematical model computer implementation in R
por: Schiesser, William E
Publicado: (2019)

Emerging Potential of the Phosphodiesterase (PDE) Inhibitor Ibudilast for Neurodegenerative Diseases: An Update on Preclinical and Clinical Evidence
por: Angelopoulou, Efthalia, et al.
Publicado: (2022)

Activation of PDE10 and PDE11
por: Jäger, Ronald, et al.
Publicado: (2011)

The Role of miR-128 in Neurodegenerative Diseases
por: Lanza, Marika, et al.
Publicado: (2023)

X‐Ray Crystallography and Free Energy Calculations Reveal the Binding Mechanism of A(2A) Adenosine Receptor Antagonists
por: Jespers, Willem, et al.
Publicado: (2020)

Potent and Subtype-Selective Dopamine D(2) Receptor Biased Partial Agonists Discovered via an Ugi-Based Approach
por: Mallo-Abreu, Ana, et al.
Publicado: (2021)

Fluorescence based HTS-compatible ligand binding assays for dopamine D(3) receptors in baculovirus preparations and live cells
por: Tahk, Maris-Johanna, et al.
Publicado: (2023)

Differential Expression and Function of PDE8 and PDE4 in Effector T cells: Implications for PDE8 as a Drug Target in Inflammation
por: Vang, Amanda G., et al.
Publicado: (2016)

Quantification of human brain PDE4 occupancy by GSK356278: A [(11)C](R)-rolipram PET study
por: van der Aart, Jasper, et al.
Publicado: (2017)

Clinical findings of end-stage retinitis pigmentosa with a homozygous PDE6A variant (p.R653X)
por: Mizobuchi, Kei, et al.
Publicado: (2018)

Computational Study on Selective PDE9 Inhibitors on PDE9-Mg/Mg, PDE9-Zn/Mg, and PDE9-Zn/Zn Systems
por: Sivakumar, Dakshinamurthy, et al.
Publicado: (2021)

Synthesis of Structurally Diverse N‐Substituted Quaternary‐Carbon‐Containing Small Molecules from α,α‐Disubstituted Propargyl Amino Esters
por: Mateu, Natalia, et al.
Publicado: (2018)

Overexpression of pdeR promotes biofilm formation of Paracoccus denitrificans by promoting ATP production and iron acquisition
por: Wang, Na, et al.
Publicado: (2022)

Fingerprint-Based Machine Learning Approach to Identify Potent and Selective 5-HT(2B)R Ligands
por: Rataj, Krzysztof, et al.
Publicado: (2018)

A Yeast-Based Chemical Screen Identifies a PDE Inhibitor That Elevates Steroidogenesis in Mouse Leydig Cells via PDE8 and PDE4 Inhibition
por: Demirbas, Didem, et al.
Publicado: (2013)

A systems genomics approach to uncover patient-specific pathogenic pathways and proteins in ulcerative colitis
por: Brooks-Warburton, Johanne, et al.
Publicado: (2022)

Central serous chorioretinopathy treatment with a systemic PDE5 and PDE6 inhibitor (sildenafil)
por: Coleman, D. Jackson, et al.
Publicado: (2020)

R-Ras GTPases Signaling Role in Myelin Neurodegenerative Diseases
por: Alcover-Sanchez, Berta, et al.
Publicado: (2020)

MiR-124 and the Underlying Therapeutic Promise of Neurodegenerative Disorders
por: Han, Dong, et al.
Publicado: (2020)

Geometric methods in PDE’s
por: Citti, Giovanna, et al.
Publicado: (2015)

Optimization with PDE constraints
por: Pinnau, Rene, et al.
Publicado: (2008)

PDE3 is the major cGMP-PDE in adult mouse ventricular cardiomyocytes
por: Götz, Konrad R, et al.
Publicado: (2013)

Reversal of neurobehavioral social deficits in dystrophic mice using inhibitors of phosphodiesterases PDE5A and PDE9A
por: Alexander, M S, et al.
Publicado: (2016)

Investigation of PDE5/PDE6 and PDE5/PDE11 selective potent tadalafil-like PDE5 inhibitors using combination of molecular modeling approaches, molecular fingerprint-based virtual screening protocols and structure-based pharmacophore development
por: Kayık, Gülru, et al.
Publicado: (2017)

Molecular inotropy mediated by cardiac miR-based PDE4D/PRKAR1α/phosphoprotein signaling
por: Bedada, Fikru B., et al.
Publicado: (2016)

Circ_WWC3 overexpression decelerates the progression of osteosarcoma by regulating miR-421/PDE7B axis
por: Liu, Sihai, et al.
Publicado: (2021)

Calcium/Calpain mediated regulation of cyclic nucleotide phosphodiesterases, PDE3A and PDE5, in human platelets
por: Rybalkina, Irina G, et al.
Publicado: (2011)

Machine learning for predicting neurodegenerative diseases in the general older population: a cohort study
por: Aguayo, Gloria A., et al.
Publicado: (2023)

PDE4 as a target in preterm labour
por: Méhats, Céline, et al.
Publicado: (2007)

Comparative analysis of PDE10A isoforms
por: Russwurm, Corina, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_sgqtcmq6mo6qi3en4nao95gcdk