Cargando…
Human genetic variation alters CRISPR-Cas9 on- and off-targeting specificity at therapeutically implicated loci
The CRISPR-Cas9 nuclease system holds enormous potential for therapeutic genome editing of a wide spectrum of diseases. Large efforts have been made to further understanding of on- and off-target activity to assist the design of CRISPR-based therapies with optimized efficacy and safety. However, cur...
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2017
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748207/ https://www.ncbi.nlm.nih.gov/pubmed/29229813 http://dx.doi.org/10.1073/pnas.1714640114 |