Cargando…
Inhibiting Interleukin 17 Can Ameliorate the Demyelination Caused by A. cantonensis via iNOS Inhibition
Angiostrongylus cantonensis (A. cantonensis) is an important food-borne parasitic disease. Previous study showed that A. cantonensis infection can cause demyelination in the central nerve system, but the mechanism of action has not been understood. To explore the mechanism and to look for effective...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748302/ https://www.ncbi.nlm.nih.gov/pubmed/29403160 http://dx.doi.org/10.1155/2017/3513651 |
_version_ | 1783289381103075328 |
---|---|
author | Ying, Feng Cunjing, Zheng Feng, Feng Shuo, Wan Xin, Zeng Fukang, Xie Zhongdao, Wu |
author_facet | Ying, Feng Cunjing, Zheng Feng, Feng Shuo, Wan Xin, Zeng Fukang, Xie Zhongdao, Wu |
author_sort | Ying, Feng |
collection | PubMed |
description | Angiostrongylus cantonensis (A. cantonensis) is an important food-borne parasitic disease. Previous study showed that A. cantonensis infection can cause demyelination in the central nerve system, but the mechanism of action has not been understood. To explore the mechanism and to look for effective therapeutic methods, interleukin 17A (IL-17A) and iNOS expressions were detected during A. cantonensis infection. In addition, IL-17A-neutralizing antibody was applied to treat A. cantonensis-infected mice. In our results, we found that IL-17A and iNOS RNA expressions increased gradually in the process of A. cantonensis infection. When infected mice were treated with IL-17A-neutralizing antibody, the pathologic changes of demyelination alleviated obviously, followed with the elevation of myelin basic protein (MBP) in the brain. In addition, the iNOS expression of the brain in infected animals also showed a decrease in astrocytes. Our study provided evidence that IL-17A may take part in the demyelination caused by A. cantonensis and inhibiting IL-17A expression can ameliorate the pathologic changes of demyelination. Moreover, the decreasing of iNOS expression may be the key reason for the effect of IL-17A inhibition on demyelination caused by A. cantonensis. |
format | Online Article Text |
id | pubmed-5748302 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-57483022018-02-05 Inhibiting Interleukin 17 Can Ameliorate the Demyelination Caused by A. cantonensis via iNOS Inhibition Ying, Feng Cunjing, Zheng Feng, Feng Shuo, Wan Xin, Zeng Fukang, Xie Zhongdao, Wu Mediators Inflamm Research Article Angiostrongylus cantonensis (A. cantonensis) is an important food-borne parasitic disease. Previous study showed that A. cantonensis infection can cause demyelination in the central nerve system, but the mechanism of action has not been understood. To explore the mechanism and to look for effective therapeutic methods, interleukin 17A (IL-17A) and iNOS expressions were detected during A. cantonensis infection. In addition, IL-17A-neutralizing antibody was applied to treat A. cantonensis-infected mice. In our results, we found that IL-17A and iNOS RNA expressions increased gradually in the process of A. cantonensis infection. When infected mice were treated with IL-17A-neutralizing antibody, the pathologic changes of demyelination alleviated obviously, followed with the elevation of myelin basic protein (MBP) in the brain. In addition, the iNOS expression of the brain in infected animals also showed a decrease in astrocytes. Our study provided evidence that IL-17A may take part in the demyelination caused by A. cantonensis and inhibiting IL-17A expression can ameliorate the pathologic changes of demyelination. Moreover, the decreasing of iNOS expression may be the key reason for the effect of IL-17A inhibition on demyelination caused by A. cantonensis. Hindawi 2017 2017-12-18 /pmc/articles/PMC5748302/ /pubmed/29403160 http://dx.doi.org/10.1155/2017/3513651 Text en Copyright © 2017 Feng Ying et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Ying, Feng Cunjing, Zheng Feng, Feng Shuo, Wan Xin, Zeng Fukang, Xie Zhongdao, Wu Inhibiting Interleukin 17 Can Ameliorate the Demyelination Caused by A. cantonensis via iNOS Inhibition |
title | Inhibiting Interleukin 17 Can Ameliorate the Demyelination Caused by A. cantonensis via iNOS Inhibition |
title_full | Inhibiting Interleukin 17 Can Ameliorate the Demyelination Caused by A. cantonensis via iNOS Inhibition |
title_fullStr | Inhibiting Interleukin 17 Can Ameliorate the Demyelination Caused by A. cantonensis via iNOS Inhibition |
title_full_unstemmed | Inhibiting Interleukin 17 Can Ameliorate the Demyelination Caused by A. cantonensis via iNOS Inhibition |
title_short | Inhibiting Interleukin 17 Can Ameliorate the Demyelination Caused by A. cantonensis via iNOS Inhibition |
title_sort | inhibiting interleukin 17 can ameliorate the demyelination caused by a. cantonensis via inos inhibition |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748302/ https://www.ncbi.nlm.nih.gov/pubmed/29403160 http://dx.doi.org/10.1155/2017/3513651 |
work_keys_str_mv | AT yingfeng inhibitinginterleukin17canamelioratethedemyelinationcausedbyacantonensisviainosinhibition AT cunjingzheng inhibitinginterleukin17canamelioratethedemyelinationcausedbyacantonensisviainosinhibition AT fengfeng inhibitinginterleukin17canamelioratethedemyelinationcausedbyacantonensisviainosinhibition AT shuowan inhibitinginterleukin17canamelioratethedemyelinationcausedbyacantonensisviainosinhibition AT xinzeng inhibitinginterleukin17canamelioratethedemyelinationcausedbyacantonensisviainosinhibition AT fukangxie inhibitinginterleukin17canamelioratethedemyelinationcausedbyacantonensisviainosinhibition AT zhongdaowu inhibitinginterleukin17canamelioratethedemyelinationcausedbyacantonensisviainosinhibition |