Cargando…

Inhibiting Interleukin 17 Can Ameliorate the Demyelination Caused by A. cantonensis via iNOS Inhibition

Angiostrongylus cantonensis (A. cantonensis) is an important food-borne parasitic disease. Previous study showed that A. cantonensis infection can cause demyelination in the central nerve system, but the mechanism of action has not been understood. To explore the mechanism and to look for effective...

Descripción completa

Detalles Bibliográficos
Autores principales: Ying, Feng, Cunjing, Zheng, Feng, Feng, Shuo, Wan, Xin, Zeng, Fukang, Xie, Zhongdao, Wu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748302/
https://www.ncbi.nlm.nih.gov/pubmed/29403160
http://dx.doi.org/10.1155/2017/3513651
_version_ 1783289381103075328
author Ying, Feng
Cunjing, Zheng
Feng, Feng
Shuo, Wan
Xin, Zeng
Fukang, Xie
Zhongdao, Wu
author_facet Ying, Feng
Cunjing, Zheng
Feng, Feng
Shuo, Wan
Xin, Zeng
Fukang, Xie
Zhongdao, Wu
author_sort Ying, Feng
collection PubMed
description Angiostrongylus cantonensis (A. cantonensis) is an important food-borne parasitic disease. Previous study showed that A. cantonensis infection can cause demyelination in the central nerve system, but the mechanism of action has not been understood. To explore the mechanism and to look for effective therapeutic methods, interleukin 17A (IL-17A) and iNOS expressions were detected during A. cantonensis infection. In addition, IL-17A-neutralizing antibody was applied to treat A. cantonensis-infected mice. In our results, we found that IL-17A and iNOS RNA expressions increased gradually in the process of A. cantonensis infection. When infected mice were treated with IL-17A-neutralizing antibody, the pathologic changes of demyelination alleviated obviously, followed with the elevation of myelin basic protein (MBP) in the brain. In addition, the iNOS expression of the brain in infected animals also showed a decrease in astrocytes. Our study provided evidence that IL-17A may take part in the demyelination caused by A. cantonensis and inhibiting IL-17A expression can ameliorate the pathologic changes of demyelination. Moreover, the decreasing of iNOS expression may be the key reason for the effect of IL-17A inhibition on demyelination caused by A. cantonensis.
format Online
Article
Text
id pubmed-5748302
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-57483022018-02-05 Inhibiting Interleukin 17 Can Ameliorate the Demyelination Caused by A. cantonensis via iNOS Inhibition Ying, Feng Cunjing, Zheng Feng, Feng Shuo, Wan Xin, Zeng Fukang, Xie Zhongdao, Wu Mediators Inflamm Research Article Angiostrongylus cantonensis (A. cantonensis) is an important food-borne parasitic disease. Previous study showed that A. cantonensis infection can cause demyelination in the central nerve system, but the mechanism of action has not been understood. To explore the mechanism and to look for effective therapeutic methods, interleukin 17A (IL-17A) and iNOS expressions were detected during A. cantonensis infection. In addition, IL-17A-neutralizing antibody was applied to treat A. cantonensis-infected mice. In our results, we found that IL-17A and iNOS RNA expressions increased gradually in the process of A. cantonensis infection. When infected mice were treated with IL-17A-neutralizing antibody, the pathologic changes of demyelination alleviated obviously, followed with the elevation of myelin basic protein (MBP) in the brain. In addition, the iNOS expression of the brain in infected animals also showed a decrease in astrocytes. Our study provided evidence that IL-17A may take part in the demyelination caused by A. cantonensis and inhibiting IL-17A expression can ameliorate the pathologic changes of demyelination. Moreover, the decreasing of iNOS expression may be the key reason for the effect of IL-17A inhibition on demyelination caused by A. cantonensis. Hindawi 2017 2017-12-18 /pmc/articles/PMC5748302/ /pubmed/29403160 http://dx.doi.org/10.1155/2017/3513651 Text en Copyright © 2017 Feng Ying et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ying, Feng
Cunjing, Zheng
Feng, Feng
Shuo, Wan
Xin, Zeng
Fukang, Xie
Zhongdao, Wu
Inhibiting Interleukin 17 Can Ameliorate the Demyelination Caused by A. cantonensis via iNOS Inhibition
title Inhibiting Interleukin 17 Can Ameliorate the Demyelination Caused by A. cantonensis via iNOS Inhibition
title_full Inhibiting Interleukin 17 Can Ameliorate the Demyelination Caused by A. cantonensis via iNOS Inhibition
title_fullStr Inhibiting Interleukin 17 Can Ameliorate the Demyelination Caused by A. cantonensis via iNOS Inhibition
title_full_unstemmed Inhibiting Interleukin 17 Can Ameliorate the Demyelination Caused by A. cantonensis via iNOS Inhibition
title_short Inhibiting Interleukin 17 Can Ameliorate the Demyelination Caused by A. cantonensis via iNOS Inhibition
title_sort inhibiting interleukin 17 can ameliorate the demyelination caused by a. cantonensis via inos inhibition
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748302/
https://www.ncbi.nlm.nih.gov/pubmed/29403160
http://dx.doi.org/10.1155/2017/3513651
work_keys_str_mv AT yingfeng inhibitinginterleukin17canamelioratethedemyelinationcausedbyacantonensisviainosinhibition
AT cunjingzheng inhibitinginterleukin17canamelioratethedemyelinationcausedbyacantonensisviainosinhibition
AT fengfeng inhibitinginterleukin17canamelioratethedemyelinationcausedbyacantonensisviainosinhibition
AT shuowan inhibitinginterleukin17canamelioratethedemyelinationcausedbyacantonensisviainosinhibition
AT xinzeng inhibitinginterleukin17canamelioratethedemyelinationcausedbyacantonensisviainosinhibition
AT fukangxie inhibitinginterleukin17canamelioratethedemyelinationcausedbyacantonensisviainosinhibition
AT zhongdaowu inhibitinginterleukin17canamelioratethedemyelinationcausedbyacantonensisviainosinhibition