MYC-dependent downregulation of telomerase by FLT3 inhibitors is required for their therapeutic efficacy on acute myeloid leukemia

The somatic mutation of FLT3 occurs in 30% of acute myeloid leukemia (AML), with the majority of mutations exhibiting internal tandem duplication (ITD). On the other hand, the induction of telomerase reverse transcriptase (hTERT) and the activation of telomerase is a key step in AML development. Her...

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Detalles Bibliográficos
Autores principales: Zhang, Xiaolu, Li, Bingnan, Yu, Jingya, Dahlström, Jenny, Tran, Anh Nhi, Björkhom, Magnus, Xu, Dawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748426/
https://www.ncbi.nlm.nih.gov/pubmed/29080039
http://dx.doi.org/10.1007/s00277-017-3158-8

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