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MYC-dependent downregulation of telomerase by FLT3 inhibitors is required for their therapeutic efficacy on acute myeloid leukemia
The somatic mutation of FLT3 occurs in 30% of acute myeloid leukemia (AML), with the majority of mutations exhibiting internal tandem duplication (ITD). On the other hand, the induction of telomerase reverse transcriptase (hTERT) and the activation of telomerase is a key step in AML development. Her...
Autores principales: | Zhang, Xiaolu, Li, Bingnan, Yu, Jingya, Dahlström, Jenny, Tran, Anh Nhi, Björkhom, Magnus, Xu, Dawei |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748426/ https://www.ncbi.nlm.nih.gov/pubmed/29080039 http://dx.doi.org/10.1007/s00277-017-3158-8 |
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