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A Study of prevalence of Shigella species and antimicrobial resistance patterns in paediatric medical center, Ahvaz, Iran

BACKGROUND AND OBJECTIVES: Shigella infections are one of the major causes of diarrhea worldwide, and especially in developing countries. Antimicrobial resistance has complicated the empirical treatment. The aim of this study was to define the clinical and antibiotic resistance patterns of Shigella...

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Autores principales: Nikfar, Roya, Shamsizadeh, Ahmad, Darbor, Marjan, Khaghani, Soheila, Moghaddam, Mina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748446/
https://www.ncbi.nlm.nih.gov/pubmed/29296272
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author Nikfar, Roya
Shamsizadeh, Ahmad
Darbor, Marjan
Khaghani, Soheila
Moghaddam, Mina
author_facet Nikfar, Roya
Shamsizadeh, Ahmad
Darbor, Marjan
Khaghani, Soheila
Moghaddam, Mina
author_sort Nikfar, Roya
collection PubMed
description BACKGROUND AND OBJECTIVES: Shigella infections are one of the major causes of diarrhea worldwide, and especially in developing countries. Antimicrobial resistance has complicated the empirical treatment. The aim of this study was to define the clinical and antibiotic resistance patterns of Shigella gastroenteritis cases. MATERIALS AND METHODS: Stool samples of patients with diarrhea and fever diagnosed with shigellosis were collected, from June 2013 to May 2014 at Abuzar Hospital, Iran. All samples were cultured for Shigella spp on selective and differential media. Shigella isolates were evaluated for antimicrobial resistance. RESULTS: Among 193 Shigella isolates, S. flexneri (64.8%) was the predominant species followed by S. sonnei (32.6%). The most frequent antibiotic resistance observed, was towards co-trimoxazole (89%), ampicillin (77%) and ceftriaxone (51%) and the lowest resistance were seen in ciprofloxacin (1.5%), azithromycin (7%). CONCLUSION: Due to the high resistance to ceftriaxone, this drug is not recommended as an empirical therapy for shigellosis. However, azithromycin should be used as the first-line treatment for paediatric patients, suffering from shigellosis and ciprofloxacin can be used as an alternative.
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spelling pubmed-57484462018-01-02 A Study of prevalence of Shigella species and antimicrobial resistance patterns in paediatric medical center, Ahvaz, Iran Nikfar, Roya Shamsizadeh, Ahmad Darbor, Marjan Khaghani, Soheila Moghaddam, Mina Iran J Microbiol Original Article BACKGROUND AND OBJECTIVES: Shigella infections are one of the major causes of diarrhea worldwide, and especially in developing countries. Antimicrobial resistance has complicated the empirical treatment. The aim of this study was to define the clinical and antibiotic resistance patterns of Shigella gastroenteritis cases. MATERIALS AND METHODS: Stool samples of patients with diarrhea and fever diagnosed with shigellosis were collected, from June 2013 to May 2014 at Abuzar Hospital, Iran. All samples were cultured for Shigella spp on selective and differential media. Shigella isolates were evaluated for antimicrobial resistance. RESULTS: Among 193 Shigella isolates, S. flexneri (64.8%) was the predominant species followed by S. sonnei (32.6%). The most frequent antibiotic resistance observed, was towards co-trimoxazole (89%), ampicillin (77%) and ceftriaxone (51%) and the lowest resistance were seen in ciprofloxacin (1.5%), azithromycin (7%). CONCLUSION: Due to the high resistance to ceftriaxone, this drug is not recommended as an empirical therapy for shigellosis. However, azithromycin should be used as the first-line treatment for paediatric patients, suffering from shigellosis and ciprofloxacin can be used as an alternative. Tehran University of Medical Sciences 2017-10 /pmc/articles/PMC5748446/ /pubmed/29296272 Text en Copyright© 2017 Iranian Neuroscience Society http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Nikfar, Roya
Shamsizadeh, Ahmad
Darbor, Marjan
Khaghani, Soheila
Moghaddam, Mina
A Study of prevalence of Shigella species and antimicrobial resistance patterns in paediatric medical center, Ahvaz, Iran
title A Study of prevalence of Shigella species and antimicrobial resistance patterns in paediatric medical center, Ahvaz, Iran
title_full A Study of prevalence of Shigella species and antimicrobial resistance patterns in paediatric medical center, Ahvaz, Iran
title_fullStr A Study of prevalence of Shigella species and antimicrobial resistance patterns in paediatric medical center, Ahvaz, Iran
title_full_unstemmed A Study of prevalence of Shigella species and antimicrobial resistance patterns in paediatric medical center, Ahvaz, Iran
title_short A Study of prevalence of Shigella species and antimicrobial resistance patterns in paediatric medical center, Ahvaz, Iran
title_sort study of prevalence of shigella species and antimicrobial resistance patterns in paediatric medical center, ahvaz, iran
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748446/
https://www.ncbi.nlm.nih.gov/pubmed/29296272
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