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Dietary Factors and Female Breast Cancer Risk: A Prospective Cohort Study

Breast cancer is the leading cause of cancer in females and has become a major global health priority. This prospective cohort study investigated the association of dietary factors, including food items and dietary habits, with the risk of breast cancer in Korean women. Study participants were women...

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Autores principales: Kim, Ji Hyun, Lee, Jeonghee, Jung, So-Youn, Kim, Jeongseon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748781/
https://www.ncbi.nlm.nih.gov/pubmed/29215604
http://dx.doi.org/10.3390/nu9121331
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author Kim, Ji Hyun
Lee, Jeonghee
Jung, So-Youn
Kim, Jeongseon
author_facet Kim, Ji Hyun
Lee, Jeonghee
Jung, So-Youn
Kim, Jeongseon
author_sort Kim, Ji Hyun
collection PubMed
description Breast cancer is the leading cause of cancer in females and has become a major global health priority. This prospective cohort study investigated the association of dietary factors, including food items and dietary habits, with the risk of breast cancer in Korean women. Study participants were women aged 30 years or older, recruited from the National Cancer Center in South Korea between August 2002 and May 2007. They were followed until December 2014 using the Korea Central Cancer Registry to identify breast cancer cases. Among 5046 non-pre-diagnosed cancer participants, 72 breast cancer cases were prospectively identified. Participants with breast cancer had a significantly higher educational level (college or higher: 58.3% vs. 39.5%, p = 0.01), were more likely to have ever smoked (22.2% vs. 7.8%, p < 0.001), and were more likely to have a history of benign breast tumors (10% vs. 4%, p = 0.02) than non-cases. Consumption of grilled meat conferred a significantly higher risk of breast cancer in all women (hazard ratio (HR) 1.77, 95% confidence interval (CI) 1.09–2.85) and in postmenopausal women (HR 3.06, 95% CI 1.31–7.15). High-cholesterol food intake was associated with a higher risk in all women (HR 1.69, 95% CI 1.01–2.82). Irregular meal intake was associated with an elevated risk in all women (HR 2.19, 95% CI 1.20–3.98, p for trend = 0.01) and in premenopausal women (HR 2.35, 95% CI 1.13–4.91, p for trend = 0.03). Our findings suggest that grilled meat and high-cholesterol food intake and irregular eating habits may be associated with a higher risk of breast cancer. Further studies with longer follow-up periods that include information on portion size, hormone receptor status, carcinogen levels in grilled meat, and a classification of foods by source are required.
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spelling pubmed-57487812018-01-07 Dietary Factors and Female Breast Cancer Risk: A Prospective Cohort Study Kim, Ji Hyun Lee, Jeonghee Jung, So-Youn Kim, Jeongseon Nutrients Article Breast cancer is the leading cause of cancer in females and has become a major global health priority. This prospective cohort study investigated the association of dietary factors, including food items and dietary habits, with the risk of breast cancer in Korean women. Study participants were women aged 30 years or older, recruited from the National Cancer Center in South Korea between August 2002 and May 2007. They were followed until December 2014 using the Korea Central Cancer Registry to identify breast cancer cases. Among 5046 non-pre-diagnosed cancer participants, 72 breast cancer cases were prospectively identified. Participants with breast cancer had a significantly higher educational level (college or higher: 58.3% vs. 39.5%, p = 0.01), were more likely to have ever smoked (22.2% vs. 7.8%, p < 0.001), and were more likely to have a history of benign breast tumors (10% vs. 4%, p = 0.02) than non-cases. Consumption of grilled meat conferred a significantly higher risk of breast cancer in all women (hazard ratio (HR) 1.77, 95% confidence interval (CI) 1.09–2.85) and in postmenopausal women (HR 3.06, 95% CI 1.31–7.15). High-cholesterol food intake was associated with a higher risk in all women (HR 1.69, 95% CI 1.01–2.82). Irregular meal intake was associated with an elevated risk in all women (HR 2.19, 95% CI 1.20–3.98, p for trend = 0.01) and in premenopausal women (HR 2.35, 95% CI 1.13–4.91, p for trend = 0.03). Our findings suggest that grilled meat and high-cholesterol food intake and irregular eating habits may be associated with a higher risk of breast cancer. Further studies with longer follow-up periods that include information on portion size, hormone receptor status, carcinogen levels in grilled meat, and a classification of foods by source are required. MDPI 2017-12-07 /pmc/articles/PMC5748781/ /pubmed/29215604 http://dx.doi.org/10.3390/nu9121331 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim, Ji Hyun
Lee, Jeonghee
Jung, So-Youn
Kim, Jeongseon
Dietary Factors and Female Breast Cancer Risk: A Prospective Cohort Study
title Dietary Factors and Female Breast Cancer Risk: A Prospective Cohort Study
title_full Dietary Factors and Female Breast Cancer Risk: A Prospective Cohort Study
title_fullStr Dietary Factors and Female Breast Cancer Risk: A Prospective Cohort Study
title_full_unstemmed Dietary Factors and Female Breast Cancer Risk: A Prospective Cohort Study
title_short Dietary Factors and Female Breast Cancer Risk: A Prospective Cohort Study
title_sort dietary factors and female breast cancer risk: a prospective cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748781/
https://www.ncbi.nlm.nih.gov/pubmed/29215604
http://dx.doi.org/10.3390/nu9121331
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