Cargando…
Reduced Educational Outcomes Persist into Adolescence Following Mild Iodine Deficiency in Utero, Despite Adequacy in Childhood: 15-Year Follow-Up of the Gestational Iodine Cohort Investigating Auditory Processing Speed and Working Memory
There is increasing evidence that even mild gestational iodine deficiency (GID) results in adverse neurocognitive impacts on offspring. It’s unclear, however, if these persist long-term and whether they can be ameliorated by iodine sufficiency in childhood. We followed a unique cohort (Gestational I...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748804/ https://www.ncbi.nlm.nih.gov/pubmed/29236073 http://dx.doi.org/10.3390/nu9121354 |
_version_ | 1783289477002690560 |
---|---|
author | Hynes, Kristen L. Otahal, Petr Burgess, John R. Oddy, Wendy H. Hay, Ian |
author_facet | Hynes, Kristen L. Otahal, Petr Burgess, John R. Oddy, Wendy H. Hay, Ian |
author_sort | Hynes, Kristen L. |
collection | PubMed |
description | There is increasing evidence that even mild gestational iodine deficiency (GID) results in adverse neurocognitive impacts on offspring. It’s unclear, however, if these persist long-term and whether they can be ameliorated by iodine sufficiency in childhood. We followed a unique cohort (Gestational Iodine Cohort, n = 266) where gestation occurred during a period of mild population iodine deficiency, with children subsequently growing-up in an iodine replete environment. We investigated whether associations between mild GID and reductions in literacy outcomes, observed at age 9-years, persisted into adolescence. Comparisons were made between offspring of mothers with gestational urinary iodine concentrations (UICs) ≥ 150 μg/L and < 150 μg/L. Educational outcomes were measured using Australian National Assessment Program—Literacy and Numeracy (NAPLAN) tests. Children whose mothers had UICs < 150 μg/L exhibited persistent reductions in spelling from Year 3 (10%, −41.4 points (95% Confidence Interval −65.1 to −17.6, p = 0.001)) to Year 9 (5.6%, −31.6 (−57.0 to −6.2, p = 0.015)) compared to children whose mothers had UICs ≥ 150 μg/L. Associations remained after adjustment for biological factors, socioeconomic status and adolescent UIC. Results support the hypothesis that mild GID may impact working memory and auditory processing speed. The findings have important public health implications for management of iodine nutrition in pregnancy. |
format | Online Article Text |
id | pubmed-5748804 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-57488042018-01-07 Reduced Educational Outcomes Persist into Adolescence Following Mild Iodine Deficiency in Utero, Despite Adequacy in Childhood: 15-Year Follow-Up of the Gestational Iodine Cohort Investigating Auditory Processing Speed and Working Memory Hynes, Kristen L. Otahal, Petr Burgess, John R. Oddy, Wendy H. Hay, Ian Nutrients Article There is increasing evidence that even mild gestational iodine deficiency (GID) results in adverse neurocognitive impacts on offspring. It’s unclear, however, if these persist long-term and whether they can be ameliorated by iodine sufficiency in childhood. We followed a unique cohort (Gestational Iodine Cohort, n = 266) where gestation occurred during a period of mild population iodine deficiency, with children subsequently growing-up in an iodine replete environment. We investigated whether associations between mild GID and reductions in literacy outcomes, observed at age 9-years, persisted into adolescence. Comparisons were made between offspring of mothers with gestational urinary iodine concentrations (UICs) ≥ 150 μg/L and < 150 μg/L. Educational outcomes were measured using Australian National Assessment Program—Literacy and Numeracy (NAPLAN) tests. Children whose mothers had UICs < 150 μg/L exhibited persistent reductions in spelling from Year 3 (10%, −41.4 points (95% Confidence Interval −65.1 to −17.6, p = 0.001)) to Year 9 (5.6%, −31.6 (−57.0 to −6.2, p = 0.015)) compared to children whose mothers had UICs ≥ 150 μg/L. Associations remained after adjustment for biological factors, socioeconomic status and adolescent UIC. Results support the hypothesis that mild GID may impact working memory and auditory processing speed. The findings have important public health implications for management of iodine nutrition in pregnancy. MDPI 2017-12-13 /pmc/articles/PMC5748804/ /pubmed/29236073 http://dx.doi.org/10.3390/nu9121354 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hynes, Kristen L. Otahal, Petr Burgess, John R. Oddy, Wendy H. Hay, Ian Reduced Educational Outcomes Persist into Adolescence Following Mild Iodine Deficiency in Utero, Despite Adequacy in Childhood: 15-Year Follow-Up of the Gestational Iodine Cohort Investigating Auditory Processing Speed and Working Memory |
title | Reduced Educational Outcomes Persist into Adolescence Following Mild Iodine Deficiency in Utero, Despite Adequacy in Childhood: 15-Year Follow-Up of the Gestational Iodine Cohort Investigating Auditory Processing Speed and Working Memory |
title_full | Reduced Educational Outcomes Persist into Adolescence Following Mild Iodine Deficiency in Utero, Despite Adequacy in Childhood: 15-Year Follow-Up of the Gestational Iodine Cohort Investigating Auditory Processing Speed and Working Memory |
title_fullStr | Reduced Educational Outcomes Persist into Adolescence Following Mild Iodine Deficiency in Utero, Despite Adequacy in Childhood: 15-Year Follow-Up of the Gestational Iodine Cohort Investigating Auditory Processing Speed and Working Memory |
title_full_unstemmed | Reduced Educational Outcomes Persist into Adolescence Following Mild Iodine Deficiency in Utero, Despite Adequacy in Childhood: 15-Year Follow-Up of the Gestational Iodine Cohort Investigating Auditory Processing Speed and Working Memory |
title_short | Reduced Educational Outcomes Persist into Adolescence Following Mild Iodine Deficiency in Utero, Despite Adequacy in Childhood: 15-Year Follow-Up of the Gestational Iodine Cohort Investigating Auditory Processing Speed and Working Memory |
title_sort | reduced educational outcomes persist into adolescence following mild iodine deficiency in utero, despite adequacy in childhood: 15-year follow-up of the gestational iodine cohort investigating auditory processing speed and working memory |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748804/ https://www.ncbi.nlm.nih.gov/pubmed/29236073 http://dx.doi.org/10.3390/nu9121354 |
work_keys_str_mv | AT hyneskristenl reducededucationaloutcomespersistintoadolescencefollowingmildiodinedeficiencyinuterodespiteadequacyinchildhood15yearfollowupofthegestationaliodinecohortinvestigatingauditoryprocessingspeedandworkingmemory AT otahalpetr reducededucationaloutcomespersistintoadolescencefollowingmildiodinedeficiencyinuterodespiteadequacyinchildhood15yearfollowupofthegestationaliodinecohortinvestigatingauditoryprocessingspeedandworkingmemory AT burgessjohnr reducededucationaloutcomespersistintoadolescencefollowingmildiodinedeficiencyinuterodespiteadequacyinchildhood15yearfollowupofthegestationaliodinecohortinvestigatingauditoryprocessingspeedandworkingmemory AT oddywendyh reducededucationaloutcomespersistintoadolescencefollowingmildiodinedeficiencyinuterodespiteadequacyinchildhood15yearfollowupofthegestationaliodinecohortinvestigatingauditoryprocessingspeedandworkingmemory AT hayian reducededucationaloutcomespersistintoadolescencefollowingmildiodinedeficiencyinuterodespiteadequacyinchildhood15yearfollowupofthegestationaliodinecohortinvestigatingauditoryprocessingspeedandworkingmemory |