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Anti-Atherogenic Activity of Polyphenol-Rich Extract from Bee Pollen

The aim of this study was to determine the effect of polyphenol-rich ethanol extract of bee pollen (EEP) on atherosclerosis induced by a high-fat diet in ApoE-knockout mice. EEP was given with feed in two doses of 0.1 and 1 g/kg body mass (BM). The studies have been conducted in a period of 16 weeks...

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Autores principales: Rzepecka-Stojko, Anna, Stojko, Jerzy, Jasik, Krzysztof, Buszman, Ewa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748819/
https://www.ncbi.nlm.nih.gov/pubmed/29258230
http://dx.doi.org/10.3390/nu9121369
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author Rzepecka-Stojko, Anna
Stojko, Jerzy
Jasik, Krzysztof
Buszman, Ewa
author_facet Rzepecka-Stojko, Anna
Stojko, Jerzy
Jasik, Krzysztof
Buszman, Ewa
author_sort Rzepecka-Stojko, Anna
collection PubMed
description The aim of this study was to determine the effect of polyphenol-rich ethanol extract of bee pollen (EEP) on atherosclerosis induced by a high-fat diet in ApoE-knockout mice. EEP was given with feed in two doses of 0.1 and 1 g/kg body mass (BM). The studies have been conducted in a period of 16 weeks. The following factors were estimated: total cholesterol (TC), oxidized low density lipoproteins (ox-LDL), asymmetric dimethylarginine (ADMA), angiotensin-converting enzyme (ACE) and angiotensin II (ANG II) in the 5th, 10th, 12th, 14th, and 16th week of the experiment. In the last, i.e., 16th week of the studies the development of coronary artery disease (CAD) was also estimated histopathologically. Supplementing diet with EEP resulted in decreasing TC level. EEP reduced oxidative stress by lowering the levels of ox-LDL, ADMA, ANG II and ACE. EEP protected coronary arteries by significantly limiting the development of atherosclerosis (the dose of 0.1 g/kg BM) or completely preventing its occurrence (the dose of 1 g/kg BM). The obtained results demonstrate that EEP may be useful as a potential anti-atherogenic agent.
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spelling pubmed-57488192018-01-07 Anti-Atherogenic Activity of Polyphenol-Rich Extract from Bee Pollen Rzepecka-Stojko, Anna Stojko, Jerzy Jasik, Krzysztof Buszman, Ewa Nutrients Article The aim of this study was to determine the effect of polyphenol-rich ethanol extract of bee pollen (EEP) on atherosclerosis induced by a high-fat diet in ApoE-knockout mice. EEP was given with feed in two doses of 0.1 and 1 g/kg body mass (BM). The studies have been conducted in a period of 16 weeks. The following factors were estimated: total cholesterol (TC), oxidized low density lipoproteins (ox-LDL), asymmetric dimethylarginine (ADMA), angiotensin-converting enzyme (ACE) and angiotensin II (ANG II) in the 5th, 10th, 12th, 14th, and 16th week of the experiment. In the last, i.e., 16th week of the studies the development of coronary artery disease (CAD) was also estimated histopathologically. Supplementing diet with EEP resulted in decreasing TC level. EEP reduced oxidative stress by lowering the levels of ox-LDL, ADMA, ANG II and ACE. EEP protected coronary arteries by significantly limiting the development of atherosclerosis (the dose of 0.1 g/kg BM) or completely preventing its occurrence (the dose of 1 g/kg BM). The obtained results demonstrate that EEP may be useful as a potential anti-atherogenic agent. MDPI 2017-12-18 /pmc/articles/PMC5748819/ /pubmed/29258230 http://dx.doi.org/10.3390/nu9121369 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rzepecka-Stojko, Anna
Stojko, Jerzy
Jasik, Krzysztof
Buszman, Ewa
Anti-Atherogenic Activity of Polyphenol-Rich Extract from Bee Pollen
title Anti-Atherogenic Activity of Polyphenol-Rich Extract from Bee Pollen
title_full Anti-Atherogenic Activity of Polyphenol-Rich Extract from Bee Pollen
title_fullStr Anti-Atherogenic Activity of Polyphenol-Rich Extract from Bee Pollen
title_full_unstemmed Anti-Atherogenic Activity of Polyphenol-Rich Extract from Bee Pollen
title_short Anti-Atherogenic Activity of Polyphenol-Rich Extract from Bee Pollen
title_sort anti-atherogenic activity of polyphenol-rich extract from bee pollen
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748819/
https://www.ncbi.nlm.nih.gov/pubmed/29258230
http://dx.doi.org/10.3390/nu9121369
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