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Quantity and Quality of Carbohydrate Intake during Pregnancy, Newborn Body Fatness and Cardiac Autonomic Control: Conferred Cardiovascular Risk?

The fetal environment has an important influence on health and disease over the life course. Maternal nutritional status during pregnancy is potentially a powerful contributor to the intrauterine environment, and may alter offspring physiology and later life cardio-metabolic risk. Putative early lif...

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Autores principales: Mckenzie, Kirsty M., Dissanayake, Hasthi U., McMullan, Rowena, Caterson, Ian D., Celermajer, David S., Gordon, Adrienne, Hyett, Jonathan, Meroni, Alice, Phang, Melinda, Raynes-Greenow, Camille, Polson, Jaimie W., Skilton, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748825/
https://www.ncbi.nlm.nih.gov/pubmed/29257088
http://dx.doi.org/10.3390/nu9121375
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author Mckenzie, Kirsty M.
Dissanayake, Hasthi U.
McMullan, Rowena
Caterson, Ian D.
Celermajer, David S.
Gordon, Adrienne
Hyett, Jonathan
Meroni, Alice
Phang, Melinda
Raynes-Greenow, Camille
Polson, Jaimie W.
Skilton, Michael R.
author_facet Mckenzie, Kirsty M.
Dissanayake, Hasthi U.
McMullan, Rowena
Caterson, Ian D.
Celermajer, David S.
Gordon, Adrienne
Hyett, Jonathan
Meroni, Alice
Phang, Melinda
Raynes-Greenow, Camille
Polson, Jaimie W.
Skilton, Michael R.
author_sort Mckenzie, Kirsty M.
collection PubMed
description The fetal environment has an important influence on health and disease over the life course. Maternal nutritional status during pregnancy is potentially a powerful contributor to the intrauterine environment, and may alter offspring physiology and later life cardio-metabolic risk. Putative early life markers of cardio-metabolic risk include newborn body fatness and cardiac autonomic control. We sought to determine whether maternal dietary carbohydrate quantity and/or quality during pregnancy are associated with newborn body composition and cardiac autonomic function. Maternal diet during pregnancy was assessed in 142 mother-infant pairs using a validated food frequency questionnaire. Infant adiposity and body composition were assessed at birth using air-displacement plethysmography. Cardiac autonomic function was assessed as heart rate variability. The quantity of carbohydrates consumed during pregnancy, as a percentage of total energy intake, was not associated with meaningful differences in offspring birth weight, adiposity or heart rate variability (p > 0.05). There was some evidence that maternal carbohydrate quality, specifically higher fibre and lower glycemic index, is associated with higher heart rate variability in the newborn offspring (p = 0.06). This suggests that poor maternal carbohydrate quality may be an important population-level inter-generational risk factor for later cardiac and hemodynamic risk of their offspring.
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spelling pubmed-57488252018-01-07 Quantity and Quality of Carbohydrate Intake during Pregnancy, Newborn Body Fatness and Cardiac Autonomic Control: Conferred Cardiovascular Risk? Mckenzie, Kirsty M. Dissanayake, Hasthi U. McMullan, Rowena Caterson, Ian D. Celermajer, David S. Gordon, Adrienne Hyett, Jonathan Meroni, Alice Phang, Melinda Raynes-Greenow, Camille Polson, Jaimie W. Skilton, Michael R. Nutrients Article The fetal environment has an important influence on health and disease over the life course. Maternal nutritional status during pregnancy is potentially a powerful contributor to the intrauterine environment, and may alter offspring physiology and later life cardio-metabolic risk. Putative early life markers of cardio-metabolic risk include newborn body fatness and cardiac autonomic control. We sought to determine whether maternal dietary carbohydrate quantity and/or quality during pregnancy are associated with newborn body composition and cardiac autonomic function. Maternal diet during pregnancy was assessed in 142 mother-infant pairs using a validated food frequency questionnaire. Infant adiposity and body composition were assessed at birth using air-displacement plethysmography. Cardiac autonomic function was assessed as heart rate variability. The quantity of carbohydrates consumed during pregnancy, as a percentage of total energy intake, was not associated with meaningful differences in offspring birth weight, adiposity or heart rate variability (p > 0.05). There was some evidence that maternal carbohydrate quality, specifically higher fibre and lower glycemic index, is associated with higher heart rate variability in the newborn offspring (p = 0.06). This suggests that poor maternal carbohydrate quality may be an important population-level inter-generational risk factor for later cardiac and hemodynamic risk of their offspring. MDPI 2017-12-19 /pmc/articles/PMC5748825/ /pubmed/29257088 http://dx.doi.org/10.3390/nu9121375 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mckenzie, Kirsty M.
Dissanayake, Hasthi U.
McMullan, Rowena
Caterson, Ian D.
Celermajer, David S.
Gordon, Adrienne
Hyett, Jonathan
Meroni, Alice
Phang, Melinda
Raynes-Greenow, Camille
Polson, Jaimie W.
Skilton, Michael R.
Quantity and Quality of Carbohydrate Intake during Pregnancy, Newborn Body Fatness and Cardiac Autonomic Control: Conferred Cardiovascular Risk?
title Quantity and Quality of Carbohydrate Intake during Pregnancy, Newborn Body Fatness and Cardiac Autonomic Control: Conferred Cardiovascular Risk?
title_full Quantity and Quality of Carbohydrate Intake during Pregnancy, Newborn Body Fatness and Cardiac Autonomic Control: Conferred Cardiovascular Risk?
title_fullStr Quantity and Quality of Carbohydrate Intake during Pregnancy, Newborn Body Fatness and Cardiac Autonomic Control: Conferred Cardiovascular Risk?
title_full_unstemmed Quantity and Quality of Carbohydrate Intake during Pregnancy, Newborn Body Fatness and Cardiac Autonomic Control: Conferred Cardiovascular Risk?
title_short Quantity and Quality of Carbohydrate Intake during Pregnancy, Newborn Body Fatness and Cardiac Autonomic Control: Conferred Cardiovascular Risk?
title_sort quantity and quality of carbohydrate intake during pregnancy, newborn body fatness and cardiac autonomic control: conferred cardiovascular risk?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748825/
https://www.ncbi.nlm.nih.gov/pubmed/29257088
http://dx.doi.org/10.3390/nu9121375
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