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Peripheral Endocannabinoid Responses to Hedonic Eating in Binge-Eating Disorder

Reward mechanisms are likely implicated in the pathophysiology of binge-eating behaviour, which is a key symptom of binge-eating disorder (BED). Since endocannabinoids modulate food-related reward, we aimed to investigate the responses of anandamide (AEA) and 2-arachidonoylglycerol (2-AG) to hedonic...

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Autores principales: Monteleone, Alessio Maria, Piscitelli, Fabiana, Dalle Grave, Riccardo, El Ghoch, Marwan, Di Marzo, Vincenzo, Maj, Mario, Monteleone, Palmiero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748827/
https://www.ncbi.nlm.nih.gov/pubmed/29261146
http://dx.doi.org/10.3390/nu9121377
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author Monteleone, Alessio Maria
Piscitelli, Fabiana
Dalle Grave, Riccardo
El Ghoch, Marwan
Di Marzo, Vincenzo
Maj, Mario
Monteleone, Palmiero
author_facet Monteleone, Alessio Maria
Piscitelli, Fabiana
Dalle Grave, Riccardo
El Ghoch, Marwan
Di Marzo, Vincenzo
Maj, Mario
Monteleone, Palmiero
author_sort Monteleone, Alessio Maria
collection PubMed
description Reward mechanisms are likely implicated in the pathophysiology of binge-eating behaviour, which is a key symptom of binge-eating disorder (BED). Since endocannabinoids modulate food-related reward, we aimed to investigate the responses of anandamide (AEA) and 2-arachidonoylglycerol (2-AG) to hedonic eating in patients with BED. Peripheral levels of AEA and 2-AG were measured in 7 obese BED patients before and after eating favorite (hedonic eating) and non-favorite (non-hedonic eating) foods. We found that plasma levels of AEA progressively decreased after eating the non-favorite food and significantly increased after eating the favorite food, whereas plasma levels of 2-AG did not differ significantly between the two test conditions, although they showed a trend toward significantly different time patterns. The changes in peripheral AEA levels were positively correlated to the subjects’ sensations of the urge to eat and the pleasantness while eating the presented food, while changes in peripheral 2-AG levels were positively correlated to the subjects’ sensation of the pleasantness while eating the presented food and to the amount of food they would eat. These results suggest the occurrence of distinctive responses of endocannabinoids to food-related reward in BED. The relevance of such findings to the pathophysiology of BED remains to be elucidated.
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spelling pubmed-57488272018-01-07 Peripheral Endocannabinoid Responses to Hedonic Eating in Binge-Eating Disorder Monteleone, Alessio Maria Piscitelli, Fabiana Dalle Grave, Riccardo El Ghoch, Marwan Di Marzo, Vincenzo Maj, Mario Monteleone, Palmiero Nutrients Article Reward mechanisms are likely implicated in the pathophysiology of binge-eating behaviour, which is a key symptom of binge-eating disorder (BED). Since endocannabinoids modulate food-related reward, we aimed to investigate the responses of anandamide (AEA) and 2-arachidonoylglycerol (2-AG) to hedonic eating in patients with BED. Peripheral levels of AEA and 2-AG were measured in 7 obese BED patients before and after eating favorite (hedonic eating) and non-favorite (non-hedonic eating) foods. We found that plasma levels of AEA progressively decreased after eating the non-favorite food and significantly increased after eating the favorite food, whereas plasma levels of 2-AG did not differ significantly between the two test conditions, although they showed a trend toward significantly different time patterns. The changes in peripheral AEA levels were positively correlated to the subjects’ sensations of the urge to eat and the pleasantness while eating the presented food, while changes in peripheral 2-AG levels were positively correlated to the subjects’ sensation of the pleasantness while eating the presented food and to the amount of food they would eat. These results suggest the occurrence of distinctive responses of endocannabinoids to food-related reward in BED. The relevance of such findings to the pathophysiology of BED remains to be elucidated. MDPI 2017-12-20 /pmc/articles/PMC5748827/ /pubmed/29261146 http://dx.doi.org/10.3390/nu9121377 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Monteleone, Alessio Maria
Piscitelli, Fabiana
Dalle Grave, Riccardo
El Ghoch, Marwan
Di Marzo, Vincenzo
Maj, Mario
Monteleone, Palmiero
Peripheral Endocannabinoid Responses to Hedonic Eating in Binge-Eating Disorder
title Peripheral Endocannabinoid Responses to Hedonic Eating in Binge-Eating Disorder
title_full Peripheral Endocannabinoid Responses to Hedonic Eating in Binge-Eating Disorder
title_fullStr Peripheral Endocannabinoid Responses to Hedonic Eating in Binge-Eating Disorder
title_full_unstemmed Peripheral Endocannabinoid Responses to Hedonic Eating in Binge-Eating Disorder
title_short Peripheral Endocannabinoid Responses to Hedonic Eating in Binge-Eating Disorder
title_sort peripheral endocannabinoid responses to hedonic eating in binge-eating disorder
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748827/
https://www.ncbi.nlm.nih.gov/pubmed/29261146
http://dx.doi.org/10.3390/nu9121377
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