Effects on Sperms’ Quality of Selegiline in Aged Rats

BACKGROUND: Selegiline is used to treat Parkinsonian patients. Other indications of its use have recently been discovered. OBJECTIVE: Scouting special and beneficial side effects of selegiline treatment. METHOD: Two-year old male Wistar rats were daily treated with 0.25 mg/kg of selegiline s.c. (sub...

Descripción completa

Detalles Bibliográficos
Autores principales: Kalász, Huba, Thuróczy, Julianna, Karvaly, Gellért, Balogh, Lajos, Gyertyán, István, Tóth-Molnár, Edit, Adeghate, Ernest, Tekes, Kornélia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Open 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748828/
https://www.ncbi.nlm.nih.gov/pubmed/29387272
http://dx.doi.org/10.2174/1874104501711010138
_version_ 1783289482690166784
author Kalász, Huba
Thuróczy, Julianna
Karvaly, Gellért
Balogh, Lajos
Gyertyán, István
Tóth-Molnár, Edit
Adeghate, Ernest
Tekes, Kornélia
author_facet Kalász, Huba
Thuróczy, Julianna
Karvaly, Gellért
Balogh, Lajos
Gyertyán, István
Tóth-Molnár, Edit
Adeghate, Ernest
Tekes, Kornélia
author_sort Kalász, Huba
collection PubMed
description BACKGROUND: Selegiline is used to treat Parkinsonian patients. Other indications of its use have recently been discovered. OBJECTIVE: Scouting special and beneficial side effects of selegiline treatment. METHOD: Two-year old male Wistar rats were daily treated with 0.25 mg/kg of selegiline s.c. (subcutaneous injection). The rats were sacrificed following a four-weeks’ treatment. RESULTS: Mass of testes, number of sperms, progressive motility of sperms, and their viability definitely increased. CONCLUSION: Selegiline can successfully be used to stop/counterbalance certain symptoms of aging.
format Online
Article
Text
id pubmed-5748828
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Bentham Open
record_format MEDLINE/PubMed
spelling pubmed-57488282018-01-31 Effects on Sperms’ Quality of Selegiline in Aged Rats Kalász, Huba Thuróczy, Julianna Karvaly, Gellért Balogh, Lajos Gyertyán, István Tóth-Molnár, Edit Adeghate, Ernest Tekes, Kornélia Open Med Chem J Article BACKGROUND: Selegiline is used to treat Parkinsonian patients. Other indications of its use have recently been discovered. OBJECTIVE: Scouting special and beneficial side effects of selegiline treatment. METHOD: Two-year old male Wistar rats were daily treated with 0.25 mg/kg of selegiline s.c. (subcutaneous injection). The rats were sacrificed following a four-weeks’ treatment. RESULTS: Mass of testes, number of sperms, progressive motility of sperms, and their viability definitely increased. CONCLUSION: Selegiline can successfully be used to stop/counterbalance certain symptoms of aging. Bentham Open 2017-11-30 /pmc/articles/PMC5748828/ /pubmed/29387272 http://dx.doi.org/10.2174/1874104501711010138 Text en © 2017 Kalász et al. https://creativecommons.org/licenses/by/4.0/legalcode This is an open access article distributed under the terms of the Creative Commons Attribution 4. 0 International Public License (CC-BY 4. 0), a copy of which is available at: https://creativecommons. org/licenses/by/4. 0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Kalász, Huba
Thuróczy, Julianna
Karvaly, Gellért
Balogh, Lajos
Gyertyán, István
Tóth-Molnár, Edit
Adeghate, Ernest
Tekes, Kornélia
Effects on Sperms’ Quality of Selegiline in Aged Rats
title Effects on Sperms’ Quality of Selegiline in Aged Rats
title_full Effects on Sperms’ Quality of Selegiline in Aged Rats
title_fullStr Effects on Sperms’ Quality of Selegiline in Aged Rats
title_full_unstemmed Effects on Sperms’ Quality of Selegiline in Aged Rats
title_short Effects on Sperms’ Quality of Selegiline in Aged Rats
title_sort effects on sperms’ quality of selegiline in aged rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748828/
https://www.ncbi.nlm.nih.gov/pubmed/29387272
http://dx.doi.org/10.2174/1874104501711010138
work_keys_str_mv AT kalaszhuba effectsonspermsqualityofselegilineinagedrats
AT thuroczyjulianna effectsonspermsqualityofselegilineinagedrats
AT karvalygellert effectsonspermsqualityofselegilineinagedrats
AT baloghlajos effectsonspermsqualityofselegilineinagedrats
AT gyertyanistvan effectsonspermsqualityofselegilineinagedrats
AT tothmolnaredit effectsonspermsqualityofselegilineinagedrats
AT adeghateernest effectsonspermsqualityofselegilineinagedrats
AT tekeskornelia effectsonspermsqualityofselegilineinagedrats

Ejemplares similares