Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase

Mutations that activate the LRRK2 (leucine-rich repeat protein kinase 2) protein kinase predispose to Parkinson's disease, suggesting that LRRK2 inhibitors might have therapeutic benefit. Recent work has revealed that LRRK2 phosphorylates a subgroup of 14 Rab proteins, including Rab10, at a spe...

Descripción completa

Detalles Bibliográficos
Autores principales: Lis, Pawel, Burel, Sophie, Steger, Martin, Mann, Matthias, Brown, Fiona, Diez, Federico, Tonelli, Francesca, Holton, Janice L., Ho, Philip Winglok, Ho, Shu-Leong, Chou, Meng-Yun, Polinski, Nicole K., Martinez, Terina N., Davies, Paul, Alessi, Dario R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748839/
https://www.ncbi.nlm.nih.gov/pubmed/29127256
http://dx.doi.org/10.1042/BCJ20170802

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748839/
https://www.ncbi.nlm.nih.gov/pubmed/29127256
http://dx.doi.org/10.1042/BCJ20170802

Ejemplares similares