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Metabolic reprogramming of human CD8(+) memory T cells through loss of SIRT1
The expansion of CD8(+)CD28(–) T cells, a population of terminally differentiated memory T cells, is one of the most consistent immunological changes in humans during aging. CD8(+)CD28(–) T cells are highly cytotoxic, and their frequency is linked to many age-related diseases. As they do not accumul...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748845/ https://www.ncbi.nlm.nih.gov/pubmed/29191913 http://dx.doi.org/10.1084/jem.20161066 |