Cilia loss sensitizes cells to transformation by activating the mevalonate pathway

Although cilia loss and cell transformation are frequently observed in the early stage of tumorigenesis, the roles of cilia in cell transformation are unknown. In this study, disrupted ciliogenesis was observed in cancer cells and pancreatic cancer tissues, which facilitated oncogene-induced transfo...

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Detalles Bibliográficos
Autores principales: Deng, Yue-Zhen, Cai, Zhen, Shi, Shuo, Jiang, Hao, Shang, Yu-Rong, Ma, Ning, Wang, Jing-Jing, Guan, Dong-Xian, Chen, Tian-Wei, Rong, Ye-Fei, Qian, Zhen-Yu, Zhang, Er-Bin, Feng, Dan, Zhou, Quan-Li, Du, Yi-Nan, Liu, Dong-Ping, Huang, Xing-Xu, Liu, Lu-Ming, Chin, Eugene, Li, Dang-Sheng, Wang, Xiao-Fan, Zhang, Xue-Li, Xie, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748847/
https://www.ncbi.nlm.nih.gov/pubmed/29237705
http://dx.doi.org/10.1084/jem.20170399

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