Development and differentiation of early innate lymphoid progenitors

Early innate lymphoid progenitors (EILPs) have recently been identified in mouse adult bone marrow as a multipotential progenitor population specified toward innate lymphoid cell (ILC) lineages, but their relationship with other described ILC progenitors is still unclear. In this study, we examine t...

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Autores principales: Harly, Christelle, Cam, Maggie, Kaye, Jonathan, Bhandoola, Avinash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748853/
https://www.ncbi.nlm.nih.gov/pubmed/29183988
http://dx.doi.org/10.1084/jem.20170832
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author Harly, Christelle
Cam, Maggie
Kaye, Jonathan
Bhandoola, Avinash
author_facet Harly, Christelle
Cam, Maggie
Kaye, Jonathan
Bhandoola, Avinash
author_sort Harly, Christelle
collection PubMed
description Early innate lymphoid progenitors (EILPs) have recently been identified in mouse adult bone marrow as a multipotential progenitor population specified toward innate lymphoid cell (ILC) lineages, but their relationship with other described ILC progenitors is still unclear. In this study, we examine the progenitor–successor relationships between EILPs, all-lymphoid progenitors (ALPs), and ILC precursors (ILCps). Functional, bioinformatic, phenotypical, and genetic approaches collectively establish EILPs as an intermediate progenitor between ALPs and ILCps. Our work additionally provides new candidate regulators of ILC development and clearly defines the stage of requirement of transcription factors key for early ILC development.
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spelling pubmed-57488532018-07-02 Development and differentiation of early innate lymphoid progenitors Harly, Christelle Cam, Maggie Kaye, Jonathan Bhandoola, Avinash J Exp Med Research Articles Early innate lymphoid progenitors (EILPs) have recently been identified in mouse adult bone marrow as a multipotential progenitor population specified toward innate lymphoid cell (ILC) lineages, but their relationship with other described ILC progenitors is still unclear. In this study, we examine the progenitor–successor relationships between EILPs, all-lymphoid progenitors (ALPs), and ILC precursors (ILCps). Functional, bioinformatic, phenotypical, and genetic approaches collectively establish EILPs as an intermediate progenitor between ALPs and ILCps. Our work additionally provides new candidate regulators of ILC development and clearly defines the stage of requirement of transcription factors key for early ILC development. The Rockefeller University Press 2018-01-02 /pmc/articles/PMC5748853/ /pubmed/29183988 http://dx.doi.org/10.1084/jem.20170832 Text en This is a work of the U.S. Government and is not subject to copyright protection in the United States. Foreign copyrights may apply. http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Research Articles
Harly, Christelle
Cam, Maggie
Kaye, Jonathan
Bhandoola, Avinash
Development and differentiation of early innate lymphoid progenitors
title Development and differentiation of early innate lymphoid progenitors
title_full Development and differentiation of early innate lymphoid progenitors
title_fullStr Development and differentiation of early innate lymphoid progenitors
title_full_unstemmed Development and differentiation of early innate lymphoid progenitors
title_short Development and differentiation of early innate lymphoid progenitors
title_sort development and differentiation of early innate lymphoid progenitors
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748853/
https://www.ncbi.nlm.nih.gov/pubmed/29183988
http://dx.doi.org/10.1084/jem.20170832
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