Novel and shared neoantigen derived from histone 3 variant H3.3K27M mutation for glioma T cell therapy

The median overall survival for children with diffuse intrinsic pontine glioma (DIPG) is less than one year. The majority of diffuse midline gliomas, including more than 70% of DIPGs, harbor an amino acid substitution from lysine (K) to methionine (M) at position 27 of histone 3 variant 3 (H3.3). Fr...

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Detalles Bibliográficos
Autores principales: Chheda, Zinal S., Kohanbash, Gary, Okada, Kaori, Jahan, Naznin, Sidney, John, Pecoraro, Matteo, Yang, Xinbo, Carrera, Diego A., Downey, Kira M., Shrivastav, Shruti, Liu, Shuming, Lin, Yi, Lagisetti, Chetana, Chuntova, Pavlina, Watchmaker, Payal B., Mueller, Sabine, Pollack, Ian F., Rajalingam, Raja, Carcaboso, Angel M., Mann, Matthias, Sette, Alessandro, Garcia, K. Christopher, Hou, Yafei, Okada, Hideho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748856/
https://www.ncbi.nlm.nih.gov/pubmed/29203539
http://dx.doi.org/10.1084/jem.20171046

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