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Organ-specific lymphatic vasculature: From development to pathophysiology

Recent discoveries of novel functions and diverse origins of lymphatic vessels have drastically changed our view of lymphatic vasculature. Traditionally regarded as passive conduits for fluid and immune cells, lymphatic vessels now emerge as active, tissue-specific players in major physiological and...

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Detalles Bibliográficos
Autores principales: Petrova, Tatiana V., Koh, Gou Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748863/
https://www.ncbi.nlm.nih.gov/pubmed/29242199
http://dx.doi.org/10.1084/jem.20171868
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author Petrova, Tatiana V.
Koh, Gou Young
author_facet Petrova, Tatiana V.
Koh, Gou Young
author_sort Petrova, Tatiana V.
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description Recent discoveries of novel functions and diverse origins of lymphatic vessels have drastically changed our view of lymphatic vasculature. Traditionally regarded as passive conduits for fluid and immune cells, lymphatic vessels now emerge as active, tissue-specific players in major physiological and pathophysiological processes. Lymphatic vessels show remarkable plasticity and heterogeneity, reflecting their functional specialization to control the tissue microenvironment. Moreover, alternative developmental origins of lymphatic endothelial cells in some organs may contribute to the diversity of their functions in adult tissues. This review aims to summarize the most recent findings of organotypic differentiation of lymphatic endothelial cells in terms of their distinct (patho)physiological functions in skin, lymph nodes, small intestine, brain, and eye. We discuss recent advances in our understanding of the heterogeneity of lymphatic vessels with respect to the organ-specific functional and molecular specialization of lymphatic endothelium, such as the hybrid blood-lymphatic identity of Schlemm’s canal, functions of intestinal lymphatics in dietary fat uptake, and discovery of meningeal lymphatic vasculature and perivascular brain lymphatic endothelial cells.
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spelling pubmed-57488632018-07-02 Organ-specific lymphatic vasculature: From development to pathophysiology Petrova, Tatiana V. Koh, Gou Young J Exp Med Reviews Recent discoveries of novel functions and diverse origins of lymphatic vessels have drastically changed our view of lymphatic vasculature. Traditionally regarded as passive conduits for fluid and immune cells, lymphatic vessels now emerge as active, tissue-specific players in major physiological and pathophysiological processes. Lymphatic vessels show remarkable plasticity and heterogeneity, reflecting their functional specialization to control the tissue microenvironment. Moreover, alternative developmental origins of lymphatic endothelial cells in some organs may contribute to the diversity of their functions in adult tissues. This review aims to summarize the most recent findings of organotypic differentiation of lymphatic endothelial cells in terms of their distinct (patho)physiological functions in skin, lymph nodes, small intestine, brain, and eye. We discuss recent advances in our understanding of the heterogeneity of lymphatic vessels with respect to the organ-specific functional and molecular specialization of lymphatic endothelium, such as the hybrid blood-lymphatic identity of Schlemm’s canal, functions of intestinal lymphatics in dietary fat uptake, and discovery of meningeal lymphatic vasculature and perivascular brain lymphatic endothelial cells. The Rockefeller University Press 2018-01-02 /pmc/articles/PMC5748863/ /pubmed/29242199 http://dx.doi.org/10.1084/jem.20171868 Text en © 2018 Petrova and Koh http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Reviews
Petrova, Tatiana V.
Koh, Gou Young
Organ-specific lymphatic vasculature: From development to pathophysiology
title Organ-specific lymphatic vasculature: From development to pathophysiology
title_full Organ-specific lymphatic vasculature: From development to pathophysiology
title_fullStr Organ-specific lymphatic vasculature: From development to pathophysiology
title_full_unstemmed Organ-specific lymphatic vasculature: From development to pathophysiology
title_short Organ-specific lymphatic vasculature: From development to pathophysiology
title_sort organ-specific lymphatic vasculature: from development to pathophysiology
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748863/
https://www.ncbi.nlm.nih.gov/pubmed/29242199
http://dx.doi.org/10.1084/jem.20171868
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