Shared cancer neoantigens: Making private matters public

In this issue of JEM, Chheda et al. (https://doi.org/10.1084/jem.20171046) report that a conserved hotspot mutation associated with an aggressive form of brain cancer generates an immunogenic T cell epitope restricted by a common HLA subtype, thereby creating a “public” neoantigen.

Detalles Bibliográficos
Autores principales: Klebanoff, Christopher A., Wolchok, Jedd D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2018
Materias:
News
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748868/
https://www.ncbi.nlm.nih.gov/pubmed/29269561
http://dx.doi.org/10.1084/jem.20172188
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author Klebanoff, Christopher A.
Wolchok, Jedd D.
author_facet Klebanoff, Christopher A.
Wolchok, Jedd D.
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description In this issue of JEM, Chheda et al. (https://doi.org/10.1084/jem.20171046) report that a conserved hotspot mutation associated with an aggressive form of brain cancer generates an immunogenic T cell epitope restricted by a common HLA subtype, thereby creating a “public” neoantigen.
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spelling pubmed-57488682018-07-02 Shared cancer neoantigens: Making private matters public Klebanoff, Christopher A. Wolchok, Jedd D. J Exp Med News In this issue of JEM, Chheda et al. (https://doi.org/10.1084/jem.20171046) report that a conserved hotspot mutation associated with an aggressive form of brain cancer generates an immunogenic T cell epitope restricted by a common HLA subtype, thereby creating a “public” neoantigen. The Rockefeller University Press 2018-01-02 /pmc/articles/PMC5748868/ /pubmed/29269561 http://dx.doi.org/10.1084/jem.20172188 Text en © 2018 Klebanoff and Wolchok http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle News
Klebanoff, Christopher A.
Wolchok, Jedd D.
Shared cancer neoantigens: Making private matters public
title Shared cancer neoantigens: Making private matters public
title_full Shared cancer neoantigens: Making private matters public
title_fullStr Shared cancer neoantigens: Making private matters public
title_full_unstemmed Shared cancer neoantigens: Making private matters public
title_short Shared cancer neoantigens: Making private matters public
title_sort shared cancer neoantigens: making private matters public
topic News
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748868/
https://www.ncbi.nlm.nih.gov/pubmed/29269561
http://dx.doi.org/10.1084/jem.20172188
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