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Energy landscape differences among integrins establish the framework for understanding activation
Why do integrins differ in basal activity, and how does affinity for soluble ligand correlate with cellular adhesiveness? We show that basal conformational equilibrium set points for integrin α(4)β(1) are cell type specific and differ from integrin α(5)β(1) when the two integrins are coexpressed on...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748972/ https://www.ncbi.nlm.nih.gov/pubmed/29122968 http://dx.doi.org/10.1083/jcb.201701169 |