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Protein sequestration at the nuclear periphery as a potential regulatory mechanism in premature aging

Despite the extensive description of numerous molecular changes associated with aging, insights into the driver mechanisms of this fundamental biological process are limited. Based on observations in the premature aging syndrome Hutchinson–Gilford progeria, we explore the possibility that protein re...

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Detalles Bibliográficos
Autores principales: Serebryannyy, Leonid, Misteli, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748986/
https://www.ncbi.nlm.nih.gov/pubmed/29051264
http://dx.doi.org/10.1083/jcb.201706061

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