Cargando…

Aurora A activation in mitosis promoted by BuGZ

Protein phase separation or coacervation has emerged as a potential mechanism to regulate biological functions. We have shown that coacervation of a mostly unstructured protein, BuGZ, promotes assembly of spindle and its matrix. BuGZ in the spindle matrix binds and concentrates tubulin to promote mi...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Yuejia, Li, Teng, Ems-McClung, Stephanie C., Walczak, Claire E., Prigent, Claude, Zhu, Xueliang, Zhang, Xuemin, Zheng, Yixian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748987/
https://www.ncbi.nlm.nih.gov/pubmed/29074706
http://dx.doi.org/10.1083/jcb.201706103