ER–mitochondria contacts: Actin dynamics at the ER control mitochondrial fission via calcium release

The formin-like protein INF2 is an important player in the polymerization of actin filaments. In this issue, Chakrabarti et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201709111) demonstrate that INF2 mediates actin polymerization at the endoplasmic reticulum (ER), resulting in increased ER...

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Detalles Bibliográficos
Autores principales: Steffen, Janos, Koehler, Carla M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2018
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748997/
https://www.ncbi.nlm.nih.gov/pubmed/29259094
http://dx.doi.org/10.1083/jcb.201711075
Descripción
Sumario:The formin-like protein INF2 is an important player in the polymerization of actin filaments. In this issue, Chakrabarti et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201709111) demonstrate that INF2 mediates actin polymerization at the endoplasmic reticulum (ER), resulting in increased ER–mitochondria contacts, calcium uptake by mitochondria, and mitochondrial division.

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