Simulating autosomal genotypes with realistic linkage disequilibrium and a spiked-in genetic effect

BACKGROUND: To evaluate statistical methods for genome-wide genetic analyses, one needs to be able to simulate realistic genotypes. We here describe a method, applicable to a broad range of association study designs, that can simulate autosome-wide single-nucleotide polymorphism data with realistic...

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Detalles Bibliográficos
Autores principales: Shi, M., Umbach, D. M., Wise, A. S., Weinberg, C. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Software
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749028/
https://www.ncbi.nlm.nih.gov/pubmed/29291710
http://dx.doi.org/10.1186/s12859-017-2004-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749028/
https://www.ncbi.nlm.nih.gov/pubmed/29291710
http://dx.doi.org/10.1186/s12859-017-2004-2

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