Cargando…
Simulating autosomal genotypes with realistic linkage disequilibrium and a spiked-in genetic effect
BACKGROUND: To evaluate statistical methods for genome-wide genetic analyses, one needs to be able to simulate realistic genotypes. We here describe a method, applicable to a broad range of association study designs, that can simulate autosome-wide single-nucleotide polymorphism data with realistic...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2018
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749028/ https://www.ncbi.nlm.nih.gov/pubmed/29291710 http://dx.doi.org/10.1186/s12859-017-2004-2 |