Cargando…
Predictors of outcome in phaeochromocytomas and paragangliomas
Phaeochromocytomas and paragangliomas (PPGLs) are catecholamine-secreting neuroendocrine tumours characterised by high rates of heritability and genetic heterogeneity. Despite advances in the genetic diagnosis and improved understanding of the molecular aberrations underlying these tumours, predicti...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
F1000 Research Limited
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749134/ https://www.ncbi.nlm.nih.gov/pubmed/29333259 http://dx.doi.org/10.12688/f1000research.12419.1 |
_version_ | 1783289539358359552 |
---|---|
author | Nicolas, Marlo Dahia, Patricia |
author_facet | Nicolas, Marlo Dahia, Patricia |
author_sort | Nicolas, Marlo |
collection | PubMed |
description | Phaeochromocytomas and paragangliomas (PPGLs) are catecholamine-secreting neuroendocrine tumours characterised by high rates of heritability and genetic heterogeneity. Despite advances in the genetic diagnosis and improved understanding of the molecular aberrations underlying these tumours, predictive markers of malignancy remain scarce, limiting the outlook of patients with metastatic PPGL. The identification of robust predictive markers remains the most pressing challenge in PPGL management, so that the potential of targeted therapy to impact patient care can be fully realised. |
format | Online Article Text |
id | pubmed-5749134 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | F1000 Research Limited |
record_format | MEDLINE/PubMed |
spelling | pubmed-57491342018-01-11 Predictors of outcome in phaeochromocytomas and paragangliomas Nicolas, Marlo Dahia, Patricia F1000Res Review Phaeochromocytomas and paragangliomas (PPGLs) are catecholamine-secreting neuroendocrine tumours characterised by high rates of heritability and genetic heterogeneity. Despite advances in the genetic diagnosis and improved understanding of the molecular aberrations underlying these tumours, predictive markers of malignancy remain scarce, limiting the outlook of patients with metastatic PPGL. The identification of robust predictive markers remains the most pressing challenge in PPGL management, so that the potential of targeted therapy to impact patient care can be fully realised. F1000 Research Limited 2017-12-21 /pmc/articles/PMC5749134/ /pubmed/29333259 http://dx.doi.org/10.12688/f1000research.12419.1 Text en Copyright: © 2017 Nicolas M and Dahia P http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Nicolas, Marlo Dahia, Patricia Predictors of outcome in phaeochromocytomas and paragangliomas |
title | Predictors of outcome in phaeochromocytomas and paragangliomas |
title_full | Predictors of outcome in phaeochromocytomas and paragangliomas |
title_fullStr | Predictors of outcome in phaeochromocytomas and paragangliomas |
title_full_unstemmed | Predictors of outcome in phaeochromocytomas and paragangliomas |
title_short | Predictors of outcome in phaeochromocytomas and paragangliomas |
title_sort | predictors of outcome in phaeochromocytomas and paragangliomas |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749134/ https://www.ncbi.nlm.nih.gov/pubmed/29333259 http://dx.doi.org/10.12688/f1000research.12419.1 |
work_keys_str_mv | AT nicolasmarlo predictorsofoutcomeinphaeochromocytomasandparagangliomas AT dahiapatricia predictorsofoutcomeinphaeochromocytomasandparagangliomas |