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Liberating cohesin from cohesion

Cohesin was identified through its major role in holding sister chromatids together. We are learning through analysis of cohesin and other members of the protein family (SMC [structural maintenance of chromosomes]) and their regulators that these ring complexes contribute to chromosome organization...

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Detalles Bibliográficos
Autor principal: Bloom, Kerry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749159/
https://www.ncbi.nlm.nih.gov/pubmed/29237741
http://dx.doi.org/10.1101/gad.309732.117
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author Bloom, Kerry
author_facet Bloom, Kerry
author_sort Bloom, Kerry
collection PubMed
description Cohesin was identified through its major role in holding sister chromatids together. We are learning through analysis of cohesin and other members of the protein family (SMC [structural maintenance of chromosomes]) and their regulators that these ring complexes contribute to chromosome organization and dynamics throughout the cell cycle. We need to consider not only how ring complexes are regulated but how they interact with their fluctuating chromatin substrate.
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spelling pubmed-57491592018-05-01 Liberating cohesin from cohesion Bloom, Kerry Genes Dev Outlook Cohesin was identified through its major role in holding sister chromatids together. We are learning through analysis of cohesin and other members of the protein family (SMC [structural maintenance of chromosomes]) and their regulators that these ring complexes contribute to chromosome organization and dynamics throughout the cell cycle. We need to consider not only how ring complexes are regulated but how they interact with their fluctuating chromatin substrate. Cold Spring Harbor Laboratory Press 2017-11-01 /pmc/articles/PMC5749159/ /pubmed/29237741 http://dx.doi.org/10.1101/gad.309732.117 Text en © 2017 Bloom; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Outlook
Bloom, Kerry
Liberating cohesin from cohesion
title Liberating cohesin from cohesion
title_full Liberating cohesin from cohesion
title_fullStr Liberating cohesin from cohesion
title_full_unstemmed Liberating cohesin from cohesion
title_short Liberating cohesin from cohesion
title_sort liberating cohesin from cohesion
topic Outlook
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749159/
https://www.ncbi.nlm.nih.gov/pubmed/29237741
http://dx.doi.org/10.1101/gad.309732.117
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