Detection of Bax Microsatellite Mutations and BaxΔ2 Isoform in Human Buccal Cells

Loss of the pro-apoptotic Bcl-2 family protein Bax occurs in ~50% of hereditary nonpolyposis colorectal cancer (HNPCC) due to microsatellite instability (MSI). Recently, we found that some of the “Bax-negative” MSI tumor cells contain a functional Bax isoform, BaxΔ2, which sensitizes cells to select...

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Detalles Bibliográficos
Autores principales: Zhang, Honghong, Tassone, Cecilie, Lin, Nora, Mañas, Adriana, Zhao, Yu, Xiang, Jialing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749267/
https://www.ncbi.nlm.nih.gov/pubmed/29302381
http://dx.doi.org/10.4172/2157-7013.S8-002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749267/
https://www.ncbi.nlm.nih.gov/pubmed/29302381
http://dx.doi.org/10.4172/2157-7013.S8-002

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