Cargando…
Detection of Bax Microsatellite Mutations and BaxΔ2 Isoform in Human Buccal Cells
Loss of the pro-apoptotic Bcl-2 family protein Bax occurs in ~50% of hereditary nonpolyposis colorectal cancer (HNPCC) due to microsatellite instability (MSI). Recently, we found that some of the “Bax-negative” MSI tumor cells contain a functional Bax isoform, BaxΔ2, which sensitizes cells to select...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749267/ https://www.ncbi.nlm.nih.gov/pubmed/29302381 http://dx.doi.org/10.4172/2157-7013.S8-002 |