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Memory enhancement and protective effects of crocin against D-galactose aging model in the hippocampus of Wistar rats
OBJECTIVE(S): The neurodegeneration and loss of memory function are common consequences of aging. Medicinal plants have potent protective effects against chronic neurodegenerative diseases. The aim of this study was to investigate the beneficial effects and molecular mechanisms of crocin on brain fu...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mashhad University of Medical Sciences
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749360/ https://www.ncbi.nlm.nih.gov/pubmed/29299203 http://dx.doi.org/10.22038/IJBMS.2017.9541 |
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author | Heidari, Somaye Mehri, Soghra Hosseinzadeh, Hossein |
author_facet | Heidari, Somaye Mehri, Soghra Hosseinzadeh, Hossein |
author_sort | Heidari, Somaye |
collection | PubMed |
description | OBJECTIVE(S): The neurodegeneration and loss of memory function are common consequences of aging. Medicinal plants have potent protective effects against chronic neurodegenerative diseases. The aim of this study was to investigate the beneficial effects and molecular mechanisms of crocin on brain function in D-galactose (D-gal)-induced aging model in rats. MATERIALS AND METHODS: Male Wistar rats weighing 220 ± 20 g were randomly divided into six groups: control, D-gal (400 mg/kg, SC), D-gal (400 mg/kg) plus crocin (7.5, 15, 30 mg/kg, IP) and crocin alone at dose of 30 mg/kg for 8 weeks. The neuroprotective effects of crocin were evaluated by Morris water maze, determination of malondialdehyde (MDA) levels and Western blot analysis. RESULTS: Crocin significantly inhibited the neurotoxic effects of D-gal through improvement of spatial learning and memory functions as well as the reduction of MDA levels. It was also found that administration of crocin up-regulated pAkt/Akt and pErk/Erk ratio which were decreased by chronic D-gal treatment. In addition, the elevated level of carboxymethyl lysine (CML), as an advance glycation product (AGE), NF-κB p65, TNFα and IL1β significantly decreased in crocin treated rats compared to D-gal group. CONCLUSION: These findings suggest that crocin is able to enhance memory function in D-gal aging model through anti-glycative and anti-oxidative properties which finally can suppress brain inflammatory mediators (IL-1, TNF and NF-κB) formations and increase PI3K/Akt and Erk/MAPK pathways activity. Therefore, crocin can be considered as healthcare product to prevent age-related brain diseases such as Alzheimer. |
format | Online Article Text |
id | pubmed-5749360 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Mashhad University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-57493602018-01-03 Memory enhancement and protective effects of crocin against D-galactose aging model in the hippocampus of Wistar rats Heidari, Somaye Mehri, Soghra Hosseinzadeh, Hossein Iran J Basic Med Sci Original Article OBJECTIVE(S): The neurodegeneration and loss of memory function are common consequences of aging. Medicinal plants have potent protective effects against chronic neurodegenerative diseases. The aim of this study was to investigate the beneficial effects and molecular mechanisms of crocin on brain function in D-galactose (D-gal)-induced aging model in rats. MATERIALS AND METHODS: Male Wistar rats weighing 220 ± 20 g were randomly divided into six groups: control, D-gal (400 mg/kg, SC), D-gal (400 mg/kg) plus crocin (7.5, 15, 30 mg/kg, IP) and crocin alone at dose of 30 mg/kg for 8 weeks. The neuroprotective effects of crocin were evaluated by Morris water maze, determination of malondialdehyde (MDA) levels and Western blot analysis. RESULTS: Crocin significantly inhibited the neurotoxic effects of D-gal through improvement of spatial learning and memory functions as well as the reduction of MDA levels. It was also found that administration of crocin up-regulated pAkt/Akt and pErk/Erk ratio which were decreased by chronic D-gal treatment. In addition, the elevated level of carboxymethyl lysine (CML), as an advance glycation product (AGE), NF-κB p65, TNFα and IL1β significantly decreased in crocin treated rats compared to D-gal group. CONCLUSION: These findings suggest that crocin is able to enhance memory function in D-gal aging model through anti-glycative and anti-oxidative properties which finally can suppress brain inflammatory mediators (IL-1, TNF and NF-κB) formations and increase PI3K/Akt and Erk/MAPK pathways activity. Therefore, crocin can be considered as healthcare product to prevent age-related brain diseases such as Alzheimer. Mashhad University of Medical Sciences 2017-11 /pmc/articles/PMC5749360/ /pubmed/29299203 http://dx.doi.org/10.22038/IJBMS.2017.9541 Text en Copyright: © Iranian Journal of Basic Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Heidari, Somaye Mehri, Soghra Hosseinzadeh, Hossein Memory enhancement and protective effects of crocin against D-galactose aging model in the hippocampus of Wistar rats |
title | Memory enhancement and protective effects of crocin against D-galactose aging model in the hippocampus of Wistar rats |
title_full | Memory enhancement and protective effects of crocin against D-galactose aging model in the hippocampus of Wistar rats |
title_fullStr | Memory enhancement and protective effects of crocin against D-galactose aging model in the hippocampus of Wistar rats |
title_full_unstemmed | Memory enhancement and protective effects of crocin against D-galactose aging model in the hippocampus of Wistar rats |
title_short | Memory enhancement and protective effects of crocin against D-galactose aging model in the hippocampus of Wistar rats |
title_sort | memory enhancement and protective effects of crocin against d-galactose aging model in the hippocampus of wistar rats |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749360/ https://www.ncbi.nlm.nih.gov/pubmed/29299203 http://dx.doi.org/10.22038/IJBMS.2017.9541 |
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