STAT5B(N642H) is a driver mutation for T cell neoplasia

STAT5B is often mutated in hematopoietic malignancies. The most frequent STAT5B mutation, Asp642His (N642H), has been found in over 90 leukemia and lymphoma patients. Here, we used the Vav1 promoter to generate transgenic mouse models that expressed either human STAT5B or STAT5B(N642H) in the hemato...

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Detalles Bibliográficos
Autores principales: Pham, Ha Thi Thanh, Maurer, Barbara, Prchal-Murphy, Michaela, Grausenburger, Reinhard, Grundschober, Eva, Javaheri, Tahereh, Nivarthi, Harini, Boersma, Auke, Kolbe, Thomas, Elabd, Mohamed, Halbritter, Florian, Pencik, Jan, Kazemi, Zahra, Grebien, Florian, Hengstschläger, Markus, Kenner, Lukas, Kubicek, Stefan, Farlik, Matthias, Bock, Christoph, Valent, Peter, Müller, Mathias, Rülicke, Thomas, Sexl, Veronika, Moriggl, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749501/
https://www.ncbi.nlm.nih.gov/pubmed/29200404
http://dx.doi.org/10.1172/JCI94509

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