SPOP mutation drives prostate neoplasia without stabilizing oncogenic transcription factor ERG

Nearly 50% of prostate cancers harbor gene fusions that lead to overexpression of the transcription factor ERG, while a mutually exclusive 10% of prostate cancers harbor recurrent mutations in the gene encoding the E3 ubiquitin ligase SPOP. Recent reports suggest that SPOP acts as a ubiquitin ligase...

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Detalles Bibliográficos
Autores principales: Shoag, Jonathan, Liu, Deli, Blattner, Mirjam, Sboner, Andrea, Park, Kyung, Deonarine, Lesa, Robinson, Brian D., Mosquera, Juan Miguel, Chen, Yu, Rubin, Mark A., Barbieri, Christopher E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2017
Materias:
Concise Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749531/
https://www.ncbi.nlm.nih.gov/pubmed/29202479
http://dx.doi.org/10.1172/JCI96551

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