Increased infiltration of M2-macrophages, T-cells and PD-L1 expression in high grade leiomyosarcomas supports immunotherapeutic strategies

Background: Immunotherapy may be a rational strategy in leiomyosarcoma (LMS), a tumor known for its genomic complexity. As a prerequisite for therapeutic applications, we characterized the immune microenvironment in LMS, as well as its prognostic value. Methods: CD163(+) macrophages, CD3(+) T-cells,...

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Detalles Bibliográficos
Autores principales: Kostine, Marie, Briaire-de Bruijn, Inge H., Cleven, Arjen H. G., Vervat, Carly, Corver, Willem E., Schilham, Marco W., Van Beelen, Els, van Boven, Hester, Haas, Rick L., Italiano, Antoine, Cleton-Jansen, Anne-Marie, Bovée, Judith V. M. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749622/
https://www.ncbi.nlm.nih.gov/pubmed/29308311
http://dx.doi.org/10.1080/2162402X.2017.1386828

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