Cargando…

Co-stimulatory signaling determines tumor antigen sensitivity and persistence of CAR T cells targeting PSCA+ metastatic prostate cancer

Advancing chimeric antigen receptor (CAR)-engineered adoptive T cells for the treatment of solid cancers is a major focus in the field of immunotherapy, given impressive recent clinical responses in hematological malignancies. Prostate cancer may be amenable to T cell-based immunotherapy since sever...

Descripción completa

Detalles Bibliográficos
Autores principales:	Priceman, Saul J., Gerdts, Ethan A., Tilakawardane, Dileshni, Kennewick, Kelly T., Murad, John P., Park, Anthony K., Jeang, Brook, Yamaguchi, Yukiko, Yang, Xin, Urak, Ryan, Weng, Lihong, Chang, Wen-Chung, Wright, Sarah, Pal, Sumanta, Reiter, Robert E., Wu, Anna M., Brown, Christine E., Forman, Stephen J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2017
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749625/ https://www.ncbi.nlm.nih.gov/pubmed/29308300 http://dx.doi.org/10.1080/2162402X.2017.1380764

Ejemplares similares

Development and optimization of PSCA-specific CAR T cells for the treatment of bone metastatic prostate cancer
por: Gerdts, Ethan, et al.
Publicado: (2015)

Pre-conditioning modifies the TME to enhance solid tumor CAR T cell efficacy and endogenous protective immunity
por: Murad, John P., et al.
Publicado: (2021)

Development of HER2-specific chimeric antigen receptor T cells for the treatment of breast-to-brain metastasis
por: Priceman, Saul, et al.
Publicado: (2015)

Development of chimeric antigen receptor (CAR) T-cell immunotherapy for glioblastoma targeting epidermal growth factor receptor variant III (EGFRvIII)
por: Park, Anthony K, et al.
Publicado: (2015)

Co-Stimulatory Receptor Signaling in CAR-T Cells
por: Honikel, Mackenzie M., et al.
Publicado: (2022)

Effective Targeting of TAG72(+) Peritoneal Ovarian Tumors via Regional Delivery of CAR-Engineered T Cells
por: Murad, John P., et al.
Publicado: (2018)

Systemic treatment with CAR-engineered T cells against PSCA delays subcutaneous tumor growth and prolongs survival of mice
por: Hillerdal, Victoria, et al.
Publicado: (2014)

Dual-Modality ImmunoPET/Fluorescence Imaging of Prostate Cancer with an Anti-PSCA Cys-Minibody
por: Tsai, Wenting K, et al.
Publicado: (2018)

PD-L1 blockade restores CAR T cell activity through IFN-γ-regulation of CD163+ M2 macrophages
por: Yamaguchi, Yukiko, et al.
Publicado: (2022)

Impact of PSCA Variation on Gastric Ulcer Susceptibility
por: Tanikawa, Chizu, et al.
Publicado: (2013)

Impact of PSCA Polymorphisms on the Risk of Duodenal Ulcer
por: Usui, Yoshiaki, et al.
Publicado: (2021)

An affinity matured minibody for PET imaging of prostate stem cell antigen (PSCA)-expressing tumors
por: Lepin, Eric J., et al.
Publicado: (2010)

Single-cell analysis by mass cytometry reveals CD19 CAR T cell spatiotemporal plasticity in patients
por: Goldberg, Lior, et al.
Publicado: (2022)

PSCA rs2294008 Polymorphism with Increased Risk of Cancer
por: Geng, Peiliang, et al.
Publicado: (2015)

Correction: Impact of PSCA Variation on Gastric Ulcer Susceptibility
Publicado: (2014)

Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting
por: Lee, Eric Hee Jun, et al.
Publicado: (2023)

Ex vivo Akt inhibition promotes the generation of potent CD19CAR T cells for adoptive immunotherapy
por: Urak, Ryan, et al.
Publicado: (2017)

The Implementation of TNFRSF Co-Stimulatory Domains in CAR-T Cells for Optimal Functional Activity
por: He, Yuan, et al.
Publicado: (2022)

Retargeting of T lymphocytes to PSCA- or PSMA positive prostate cancer cells using the novel modular chimeric antigen receptor platform technology “UniCAR”
por: Feldmann, Anja, et al.
Publicado: (2017)

PSCA polymorphisms and gastric cancer susceptibility in an eastern Chinese population
por: Qiu, Li-Xin, et al.
Publicado: (2016)

The Correlation between PSCA Expression and Neuroendocrine Differentiation in Prostate Cancer
por: Xiang, Qian, et al.
Publicado: (2020)

Exploring the Tumor-Suppressing Potential of PSCA in Pancreatic Ductal Adenocarcinoma
por: Li, Kexin, et al.
Publicado: (2023)

PSCA is a target of chimeric antigen receptor T cells in gastric cancer
por: Wu, Di, et al.
Publicado: (2020)

Downregulation of PSCA promotes gastric cancer proliferation and is related to poor prognosis
por: Xu, Li-pu, et al.
Publicado: (2020)

Genetic variation in PSCA gene and bladder cancer susceptibility in North Indian population
por: Jaiswal, Praveen K, et al.
Publicado: (2014)

PSCA rs2294008 C > T polymorphism contributes to gastric and bladder cancer risk
por: Wang, Meng, et al.
Publicado: (2015)

Single-nucleotide polymorphisms in PSCA and the risk of breast cancer in a Chinese population
por: Wang, Meng, et al.
Publicado: (2016)

Impact of PSCA gene polymorphisms in modulating gastric cancer risk in the Chinese population
por: Yan, Kangpeng, et al.
Publicado: (2019)

Genetic variation of the PSCA gene (rs2294008) is not associated with the risk of prostate cancer
por: Lee, Il-Seok, et al.
Publicado: (2017)

Optimizing the Preparation Procedure of Recombinant PSCA, as a Practical Biomarker in Prostate Cancer
por: Shahrabi Farahani, Mahboube, et al.
Publicado: (2021)

Delivery of CAR-T cells in a transient injectable stimulatory hydrogel niche improves treatment of solid tumors
por: Grosskopf, Abigail K., et al.
Publicado: (2022)

Co-stimulatory and co-inhibitory immune markers in solid tumors with MET alterations
por: Reckamp, Karen L, et al.
Publicado: (2020)

Evaluation of the Elements of Short Hairpin RNAs in Developing shRNA-Containing CAR T Cells
por: Urak, Ryan, et al.
Publicado: (2023)

Dendritic Cell-Directed Vaccination with a Lentivector Encoding PSCA for Prostate Cancer in Mice
por: Xiao, Liang, et al.
Publicado: (2012)

Diagnostic Efficacy of PSMA and PSCA mRNAs Combined to PSA in Prostate Cancer Patients
por: Mahmoud, Mustafa M, et al.
Publicado: (2023)

L1 Cell Adhesion Molecule-Specific Chimeric Antigen Receptor-Redirected Human T Cells Exhibit Specific and Efficient Antitumor Activity against Human Ovarian Cancer in Mice
por: Hong, Hao, et al.
Publicado: (2016)

Large-scale manufacturing and characterization of CMV-CD19CAR T cells
por: Wang, Xiuli, et al.
Publicado: (2022)

Prostate stem cell antigen (PSCA) and risk of bladder cancer: linking genotypes to functional mechanisms
por: Mumy, Adam, et al.
Publicado: (2011)

The therapeutic efficacy of I(131)-PSCA-mAb in orthotopic mouse models of prostate cancer
por: Yu, Shengqiang, et al.
Publicado: (2013)

The Influence of PSCA Gene Variation on Its Expression and Gastric Adenocarcinoma Susceptibility in the Northwest Chinese Population
por: Zhang, Wentao, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_pfbjadjblo5rkkeceae3ktb79g