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Probing the antigenicity of hepatitis C virus envelope glycoprotein complex by high-throughput mutagenesis

The hepatitis C virus (HCV) envelope glycoproteins E1 and E2 form a non-covalently linked heterodimer on the viral surface that mediates viral entry. E1, E2 and the heterodimer complex E1E2 are candidate vaccine antigens, but are technically challenging to study because of difficulties in producing...

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Detalles Bibliográficos
Autores principales:	Gopal, Radhika, Jackson, Kelli, Tzarum, Netanel, Kong, Leopold, Ettenger, Andrew, Guest, Johnathan, Pfaff, Jennifer M., Barnes, Trevor, Honda, Andrew, Giang, Erick, Davidson, Edgar, Wilson, Ian A., Doranz, Benjamin J., Law, Mansun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749897/ https://www.ncbi.nlm.nih.gov/pubmed/29253863 http://dx.doi.org/10.1371/journal.ppat.1006735

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