Increased autophagic sequestration in adaptor protein-3 deficient dendritic cells limits inflammasome activity and impairs antibacterial immunity

Bacterial pathogens that compromise phagosomal membranes stimulate inflammasome assembly in the cytosol, but the molecular mechanisms by which membrane dynamics regulate inflammasome activity are poorly characterized. We show that in murine dendritic cells (DCs), the endosomal adaptor protein AP-3 –...

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Detalles Bibliográficos
Autores principales: Mantegazza, Adriana R., Wynosky-Dolfi, Meghan A., Casson, Cierra N., Lefkovith, Ariel J., Shin, Sunny, Brodsky, Igor E., Marks, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749898/
https://www.ncbi.nlm.nih.gov/pubmed/29253868
http://dx.doi.org/10.1371/journal.ppat.1006785

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749898/
https://www.ncbi.nlm.nih.gov/pubmed/29253868
http://dx.doi.org/10.1371/journal.ppat.1006785

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