Mechanistic insights into the active site and allosteric communication pathways in human nonmuscle myosin-2C

Despite a generic, highly conserved motor domain, ATP turnover kinetics and their activation by F-actin vary greatly between myosin-2 isoforms. Here, we present a 2.25 Å pre-powerstroke state (ADP⋅VO(4)) crystal structure of the human nonmuscle myosin-2C motor domain, one of the slowest myosins char...

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Detalles Bibliográficos
Autores principales: Chinthalapudi, Krishna, Heissler, Sarah M, Preller, Matthias, Sellers, James R, Manstein, Dietmar J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749951/
https://www.ncbi.nlm.nih.gov/pubmed/29256864
http://dx.doi.org/10.7554/eLife.32742

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749951/
https://www.ncbi.nlm.nih.gov/pubmed/29256864
http://dx.doi.org/10.7554/eLife.32742

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