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Mechanistic insights into the active site and allosteric communication pathways in human nonmuscle myosin-2C
Despite a generic, highly conserved motor domain, ATP turnover kinetics and their activation by F-actin vary greatly between myosin-2 isoforms. Here, we present a 2.25 Å pre-powerstroke state (ADP⋅VO(4)) crystal structure of the human nonmuscle myosin-2C motor domain, one of the slowest myosins char...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749951/ https://www.ncbi.nlm.nih.gov/pubmed/29256864 http://dx.doi.org/10.7554/eLife.32742 |