Extended low-resolution structure of a Leptospira antigen offers high bactericidal antibody accessibility amenable to vaccine design

Pathogens rely on proteins embedded on their surface to perform tasks essential for host infection. These obligatory structures exposed to the host immune system provide important targets for rational vaccine design. Here, we use a systematically designed series of multi-domain constructs in combina...

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Detalles Bibliográficos
Autores principales: Hsieh, Ching-Lin, Ptak, Christopher P, Tseng, Andrew, Suguiura, Igor Massahiro de Souza, McDonough, Sean P, Sritrakul, Tepyuda, Li, Ting, Lin, Yi-Pin, Gillilan, Richard E, Oswald, Robert E, Chang, Yung-Fu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749957/
https://www.ncbi.nlm.nih.gov/pubmed/29210669
http://dx.doi.org/10.7554/eLife.30051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749957/
https://www.ncbi.nlm.nih.gov/pubmed/29210669
http://dx.doi.org/10.7554/eLife.30051

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