Construction of a junction DNA nanostructure and modulation of the junction switching to quadruplexes

A junction DNA nanostructure has been successfully built in lithium acetate buffer solution at a near-neutral pH value through the connection of two slipped junction structures that are formed by G-rich and C-rich strands. The GC-rich duplex junctions in the nanostructure can be switched to G-quadru...

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Detalles Bibliográficos
Autores principales: Cao, Yanwei, Xiang, Xiaoxuan, Pei, Renjun, Li, Yang, Yan, Yuting, Guo, Xinhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society Publishing 2017
Materias:
Biochemistry and Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750025/
https://www.ncbi.nlm.nih.gov/pubmed/29308258
http://dx.doi.org/10.1098/rsos.171337
Descripción
Sumario:A junction DNA nanostructure has been successfully built in lithium acetate buffer solution at a near-neutral pH value through the connection of two slipped junction structures that are formed by G-rich and C-rich strands. The GC-rich duplex junctions in the nanostructure can be switched to G-quadruplexes and i-motifs in weakly acidic potassium acetate solution, which leads to the assembly of DNA nanostructures composed of alternating quadruplex and duplex DNA structures. The transformation between different DNA nanoarchitectures may be applied to the operation of ‘DNA nanomachines’.

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