Construction of a junction DNA nanostructure and modulation of the junction switching to quadruplexes

A junction DNA nanostructure has been successfully built in lithium acetate buffer solution at a near-neutral pH value through the connection of two slipped junction structures that are formed by G-rich and C-rich strands. The GC-rich duplex junctions in the nanostructure can be switched to G-quadru...

Descripción completa

Detalles Bibliográficos
Autores principales: Cao, Yanwei, Xiang, Xiaoxuan, Pei, Renjun, Li, Yang, Yan, Yuting, Guo, Xinhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society Publishing 2017
Materias:
Biochemistry and Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750025/
https://www.ncbi.nlm.nih.gov/pubmed/29308258
http://dx.doi.org/10.1098/rsos.171337
_version_ 1783289683756711936
author Cao, Yanwei
Xiang, Xiaoxuan
Pei, Renjun
Li, Yang
Yan, Yuting
Guo, Xinhua
author_facet Cao, Yanwei
Xiang, Xiaoxuan
Pei, Renjun
Li, Yang
Yan, Yuting
Guo, Xinhua
author_sort Cao, Yanwei
collection PubMed
description A junction DNA nanostructure has been successfully built in lithium acetate buffer solution at a near-neutral pH value through the connection of two slipped junction structures that are formed by G-rich and C-rich strands. The GC-rich duplex junctions in the nanostructure can be switched to G-quadruplexes and i-motifs in weakly acidic potassium acetate solution, which leads to the assembly of DNA nanostructures composed of alternating quadruplex and duplex DNA structures. The transformation between different DNA nanoarchitectures may be applied to the operation of ‘DNA nanomachines’.
format Online
Article
Text
id pubmed-5750025
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher The Royal Society Publishing
record_format MEDLINE/PubMed
spelling pubmed-57500252018-01-07 Construction of a junction DNA nanostructure and modulation of the junction switching to quadruplexes Cao, Yanwei Xiang, Xiaoxuan Pei, Renjun Li, Yang Yan, Yuting Guo, Xinhua R Soc Open Sci Biochemistry and Biophysics A junction DNA nanostructure has been successfully built in lithium acetate buffer solution at a near-neutral pH value through the connection of two slipped junction structures that are formed by G-rich and C-rich strands. The GC-rich duplex junctions in the nanostructure can be switched to G-quadruplexes and i-motifs in weakly acidic potassium acetate solution, which leads to the assembly of DNA nanostructures composed of alternating quadruplex and duplex DNA structures. The transformation between different DNA nanoarchitectures may be applied to the operation of ‘DNA nanomachines’. The Royal Society Publishing 2017-12-20 /pmc/articles/PMC5750025/ /pubmed/29308258 http://dx.doi.org/10.1098/rsos.171337 Text en © 2017 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Biochemistry and Biophysics
Cao, Yanwei
Xiang, Xiaoxuan
Pei, Renjun
Li, Yang
Yan, Yuting
Guo, Xinhua
Construction of a junction DNA nanostructure and modulation of the junction switching to quadruplexes
title Construction of a junction DNA nanostructure and modulation of the junction switching to quadruplexes
title_full Construction of a junction DNA nanostructure and modulation of the junction switching to quadruplexes
title_fullStr Construction of a junction DNA nanostructure and modulation of the junction switching to quadruplexes
title_full_unstemmed Construction of a junction DNA nanostructure and modulation of the junction switching to quadruplexes
title_short Construction of a junction DNA nanostructure and modulation of the junction switching to quadruplexes
title_sort construction of a junction dna nanostructure and modulation of the junction switching to quadruplexes
topic Biochemistry and Biophysics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750025/
https://www.ncbi.nlm.nih.gov/pubmed/29308258
http://dx.doi.org/10.1098/rsos.171337
work_keys_str_mv AT caoyanwei constructionofajunctiondnananostructureandmodulationofthejunctionswitchingtoquadruplexes
AT xiangxiaoxuan constructionofajunctiondnananostructureandmodulationofthejunctionswitchingtoquadruplexes
AT peirenjun constructionofajunctiondnananostructureandmodulationofthejunctionswitchingtoquadruplexes
AT liyang constructionofajunctiondnananostructureandmodulationofthejunctionswitchingtoquadruplexes
AT yanyuting constructionofajunctiondnananostructureandmodulationofthejunctionswitchingtoquadruplexes
AT guoxinhua constructionofajunctiondnananostructureandmodulationofthejunctionswitchingtoquadruplexes

Ejemplares similares