The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity

Inflammasomes activate the protease caspase-1, which cleaves interleukin-1β and interleukin-18 to generate the mature cytokines and controls their secretion and a form of inflammatory cell death called pyroptosis. By generating mice expressing enzymatically inactive caspase-1(C284A), we provide gene...

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Detalles Bibliográficos
Autores principales: Schneider, Katharina S., Groß, Christina J., Dreier, Roland F., Saller, Benedikt S., Mishra, Ritu, Gorka, Oliver, Heilig, Rosalie, Meunier, Etienne, Dick, Mathias S., Ćiković, Tamara, Sodenkamp, Jan, Médard, Guillaume, Naumann, Ronald, Ruland, Jürgen, Kuster, Bernhard, Broz, Petr, Groß, Olaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750195/
https://www.ncbi.nlm.nih.gov/pubmed/29281832
http://dx.doi.org/10.1016/j.celrep.2017.12.018

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