Obligatory and facilitative allelic variation in the DNA methylome within common disease-associated loci

Integrating epigenetic data with genome-wide association study (GWAS) results can reveal disease mechanisms. The genome sequence itself also shapes the epigenome, with CpG density and transcription factor binding sites (TFBSs) strongly encoding the DNA methylome. Therefore, genetic polymorphism impa...

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Detalles Bibliográficos
Autores principales: Bell, Christopher G., Gao, Fei, Yuan, Wei, Roos, Leonie, Acton, Richard J., Xia, Yudong, Bell, Jordana, Ward, Kirsten, Mangino, Massimo, Hysi, Pirro G., Wang, Jun, Spector, Timothy D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750212/
https://www.ncbi.nlm.nih.gov/pubmed/29295990
http://dx.doi.org/10.1038/s41467-017-01586-1

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