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Inhibition of Poly(A)-binding protein with a synthetic RNA mimic reduces pain sensitization in mice
Nociceptors rely on cap-dependent translation to rapidly induce protein synthesis in response to pro-inflammatory signals. Comparatively little is known regarding the role of the regulatory factors bound to the 3′ end of mRNA in nociceptor sensitization. Poly(A)-binding protein (PABP) stimulates tra...
Autores principales: | Barragán-Iglesias, Paulino, Lou, Tzu-Fang, Bhat, Vandita D., Megat, Salim, Burton, Michael D., Price, Theodore J., Campbell, Zachary T. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750225/ https://www.ncbi.nlm.nih.gov/pubmed/29295980 http://dx.doi.org/10.1038/s41467-017-02449-5 |
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