Cargando…

Tricyclic Antidepressant-Induced Anticholinergic Delirium in a Young Healthy Male Individual

The tricyclic antidepressants, while older, still have their place in the treatment of depression today. They are efficacious but less selective and thus have the potential of eliciting many side effects. Anticholinergic delirium is a potential complication when using a tricyclic antidepressant or o...

Descripción completa

Detalles Bibliográficos
Autores principales: King, Matthew, Ashraf, Nauman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750324/
https://www.ncbi.nlm.nih.gov/pubmed/29294203
http://dx.doi.org/10.1007/s40800-017-0069-5
_version_ 1783289697485717504
author King, Matthew
Ashraf, Nauman
author_facet King, Matthew
Ashraf, Nauman
author_sort King, Matthew
collection PubMed
description The tricyclic antidepressants, while older, still have their place in the treatment of depression today. They are efficacious but less selective and thus have the potential of eliciting many side effects. Anticholinergic delirium is a potential complication when using a tricyclic antidepressant or other anticholinergic agent. Following the Naranjo algorithm, this case report describes a probable amitriptyline-induced delirium in a previously healthy, 36-year-old Caucasian male individual after he promptly resumed his nightly 200-mg amitriptyline dose, following abrupt discontinuation of the medication 1 week earlier. This case emphasizes the importance of drug titration/tapering and therapeutic drug monitoring of patients taking tricyclic antidepressants.
format Online
Article
Text
id pubmed-5750324
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Springer International Publishing
record_format MEDLINE/PubMed
spelling pubmed-57503242018-01-20 Tricyclic Antidepressant-Induced Anticholinergic Delirium in a Young Healthy Male Individual King, Matthew Ashraf, Nauman Drug Saf Case Rep Case Report The tricyclic antidepressants, while older, still have their place in the treatment of depression today. They are efficacious but less selective and thus have the potential of eliciting many side effects. Anticholinergic delirium is a potential complication when using a tricyclic antidepressant or other anticholinergic agent. Following the Naranjo algorithm, this case report describes a probable amitriptyline-induced delirium in a previously healthy, 36-year-old Caucasian male individual after he promptly resumed his nightly 200-mg amitriptyline dose, following abrupt discontinuation of the medication 1 week earlier. This case emphasizes the importance of drug titration/tapering and therapeutic drug monitoring of patients taking tricyclic antidepressants. Springer International Publishing 2018-01-02 /pmc/articles/PMC5750324/ /pubmed/29294203 http://dx.doi.org/10.1007/s40800-017-0069-5 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Case Report
King, Matthew
Ashraf, Nauman
Tricyclic Antidepressant-Induced Anticholinergic Delirium in a Young Healthy Male Individual
title Tricyclic Antidepressant-Induced Anticholinergic Delirium in a Young Healthy Male Individual
title_full Tricyclic Antidepressant-Induced Anticholinergic Delirium in a Young Healthy Male Individual
title_fullStr Tricyclic Antidepressant-Induced Anticholinergic Delirium in a Young Healthy Male Individual
title_full_unstemmed Tricyclic Antidepressant-Induced Anticholinergic Delirium in a Young Healthy Male Individual
title_short Tricyclic Antidepressant-Induced Anticholinergic Delirium in a Young Healthy Male Individual
title_sort tricyclic antidepressant-induced anticholinergic delirium in a young healthy male individual
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750324/
https://www.ncbi.nlm.nih.gov/pubmed/29294203
http://dx.doi.org/10.1007/s40800-017-0069-5
work_keys_str_mv AT kingmatthew tricyclicantidepressantinducedanticholinergicdeliriuminayounghealthymaleindividual
AT ashrafnauman tricyclicantidepressantinducedanticholinergicdeliriuminayounghealthymaleindividual