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Tricyclic Antidepressant-Induced Anticholinergic Delirium in a Young Healthy Male Individual
The tricyclic antidepressants, while older, still have their place in the treatment of depression today. They are efficacious but less selective and thus have the potential of eliciting many side effects. Anticholinergic delirium is a potential complication when using a tricyclic antidepressant or o...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750324/ https://www.ncbi.nlm.nih.gov/pubmed/29294203 http://dx.doi.org/10.1007/s40800-017-0069-5 |
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author | King, Matthew Ashraf, Nauman |
author_facet | King, Matthew Ashraf, Nauman |
author_sort | King, Matthew |
collection | PubMed |
description | The tricyclic antidepressants, while older, still have their place in the treatment of depression today. They are efficacious but less selective and thus have the potential of eliciting many side effects. Anticholinergic delirium is a potential complication when using a tricyclic antidepressant or other anticholinergic agent. Following the Naranjo algorithm, this case report describes a probable amitriptyline-induced delirium in a previously healthy, 36-year-old Caucasian male individual after he promptly resumed his nightly 200-mg amitriptyline dose, following abrupt discontinuation of the medication 1 week earlier. This case emphasizes the importance of drug titration/tapering and therapeutic drug monitoring of patients taking tricyclic antidepressants. |
format | Online Article Text |
id | pubmed-5750324 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-57503242018-01-20 Tricyclic Antidepressant-Induced Anticholinergic Delirium in a Young Healthy Male Individual King, Matthew Ashraf, Nauman Drug Saf Case Rep Case Report The tricyclic antidepressants, while older, still have their place in the treatment of depression today. They are efficacious but less selective and thus have the potential of eliciting many side effects. Anticholinergic delirium is a potential complication when using a tricyclic antidepressant or other anticholinergic agent. Following the Naranjo algorithm, this case report describes a probable amitriptyline-induced delirium in a previously healthy, 36-year-old Caucasian male individual after he promptly resumed his nightly 200-mg amitriptyline dose, following abrupt discontinuation of the medication 1 week earlier. This case emphasizes the importance of drug titration/tapering and therapeutic drug monitoring of patients taking tricyclic antidepressants. Springer International Publishing 2018-01-02 /pmc/articles/PMC5750324/ /pubmed/29294203 http://dx.doi.org/10.1007/s40800-017-0069-5 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Case Report King, Matthew Ashraf, Nauman Tricyclic Antidepressant-Induced Anticholinergic Delirium in a Young Healthy Male Individual |
title | Tricyclic Antidepressant-Induced Anticholinergic Delirium in a Young Healthy Male Individual |
title_full | Tricyclic Antidepressant-Induced Anticholinergic Delirium in a Young Healthy Male Individual |
title_fullStr | Tricyclic Antidepressant-Induced Anticholinergic Delirium in a Young Healthy Male Individual |
title_full_unstemmed | Tricyclic Antidepressant-Induced Anticholinergic Delirium in a Young Healthy Male Individual |
title_short | Tricyclic Antidepressant-Induced Anticholinergic Delirium in a Young Healthy Male Individual |
title_sort | tricyclic antidepressant-induced anticholinergic delirium in a young healthy male individual |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750324/ https://www.ncbi.nlm.nih.gov/pubmed/29294203 http://dx.doi.org/10.1007/s40800-017-0069-5 |
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